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Literature summary extracted from

  • Authier, F.; Rachubinski, R.A.; Posner, B.I.; Bergeron, J.M.
    Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme (1994), J. Biol. Chem., 269, 3010-3016.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.56
-
 Drosophila melanogaster
3.4.24.56
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.56 cytosol
-
 Drosophila melanogaster 5829
-
3.4.24.56 cytosol
-
 Homo sapiens 5829
-
3.4.24.56 cytosol
-
 Rattus norvegicus 5829
-
3.4.24.56 peroxisome cloned cDNAs of insulin degrading enzyme (human, rat and Drosophila melanogaster) reveal a deduced classical peroxisomal targeting sequence A/SKL at their carboxyl termini, this may account for the peroxisomal location of the enzyme Drosophila melanogaster 5777
-
3.4.24.56 peroxisome cloned cDNAs of insulin degrading enzyme (human, rat and Drosophila melanogaster) reveal a deduced classical peroxisomal targeting sequence A/SKL at their carboxyl termini, this may account for the peroxisomal location of the enzyme Homo sapiens 5777
-
3.4.24.56 peroxisome cloned cDNAs of insulin degrading enzyme (human, rat and Drosophila melanogaster) reveal a deduced classical peroxisomal targeting sequence A/SKL at their carboxyl termini, this may account for the peroxisomal location of the enzyme Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 insulin + H2O Drosophila melanogaster insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma ?
-
 ?
3.4.24.56 insulin + H2O Homo sapiens insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma ?
-
 ?
3.4.24.56 insulin + H2O Rattus norvegicus insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Drosophila melanogaster
-
-
-
3.4.24.56 Homo sapiens
-
-
-
3.4.24.56 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 Insulin + H2O
-
 Drosophila melanogaster Hydrolyzed insulin
-
 ?
3.4.24.56 Insulin + H2O
-
 Homo sapiens Hydrolyzed insulin
-
 ?
3.4.24.56 Insulin + H2O
-
 Rattus norvegicus Hydrolyzed insulin
-
 ?
3.4.24.56 insulin + H2O insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma Drosophila melanogaster ?
-
 ?
3.4.24.56 insulin + H2O insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma Homo sapiens ?
-
 ?
3.4.24.56 insulin + H2O insulin degrading enzyme is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma Rattus norvegicus ?
-
 ?