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Literature summary extracted from

  • Chowdhary, B.K.; Smith, G.D.; Peters, T.J.
    Subcellular localization and partial characterization of insulin proteolytic activity in rat liver (1985), Biochim. Biophys. Acta, 840, 180-186.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.56 Ca2+ stimulates cytosolic activity, inhibits particulate activity Rattus norvegicus
3.4.24.56 Diamide
-
 Rattus norvegicus
3.4.24.56 Mg2+ stimulates cytosolic activity, inhibits particulate activity Rattus norvegicus
3.4.24.56 additional information not: leupeptin; not: pepstatin Rattus norvegicus
3.4.24.56 Zn2+ ZnCl2 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.56 0.005 0.007 Insulin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.56 cytosol
-
 Rattus norvegicus 5829
-
3.4.24.56 endoplasmic reticulum membrane-associated activity is highly latent Rattus norvegicus 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.56 Ca2+ stimulates cytosolic activity, inhibits particulate activity Rattus norvegicus
3.4.24.56 Mg2+ stimulates cytosolic activity, inhibits particulate activity Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.56 300000
-
 rat, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 Insulin + H2O
-
 Rattus norvegicus Hydrolyzed insulin
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.56 7
-
-
 Rattus norvegicus