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Literature summary extracted from

  • Duckworth, W.C.; Hamel, F.G.; Bennett, R.; Ryan, M.P.; Roth, R.A.
    Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin (1990), J. Biol. Chem., 265, 2984-2987.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.56 Ca2+ chelator-treated enzyme can be reactivated by Ca2+ Homo sapiens
3.4.24.56 Ca2+ chelator-treated enzyme can be reactivated by Ca2+ Rattus norvegicus
3.4.24.56 Mn2+ chelator-treated enzyme can be reactivated by Mn2+ Homo sapiens
3.4.24.56 Mn2+ chelator-treated enzyme can be reactivated by Mn2+ Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.56 110000
-
x * 110000, human, SDS-PAGE Homo sapiens
3.4.24.56 110000
-
x * 110000, human, SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Homo sapiens
-
-
-
3.4.24.56 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.56
-
Homo sapiens
3.4.24.56
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 erythrocyte
-
Homo sapiens
-
3.4.24.56 skeletal muscle
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 Insulin + H2O
-
Homo sapiens Hydrolyzed insulin
-
?
3.4.24.56 Insulin + H2O
-
Rattus norvegicus Hydrolyzed insulin
-
?

Subunits

EC Number Subunits Comment Organism
3.4.24.56 ? x * 110000, human, SDS-PAGE Homo sapiens
3.4.24.56 ? x * 110000, human, SDS-PAGE Rattus norvegicus