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Literature summary extracted from

  • Civello, D.J.; Moran, J.B.; Geren, C.R.
    Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom (1983), Biochemistry, 22, 755-762.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.47 Ca2+
-
 Crotalus horridus horridus
3.4.24.47 Zn2+ 1 mol zinc/mol enzyme Crotalus horridus horridus
3.4.24.47 Zn2+ activation, 1 mM Zn2+ doubles activity vs. glomerulus basement membrane preparation Crotalus horridus horridus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.47 Crotalus horridus horridus
-
 Timber rattlesnake
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.47 venom
-
 Crotalus horridus horridus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.47 Basement membrane preparation + H2O from glomeruli Crotalus horridus horridus ?
-
 ?
3.4.24.47 Bee venom melittin + H2O cleaves at Ile2-Gly3, Pro14-Ala15, Ser18-Trp19 Crotalus horridus horridus ?
-
 ?
3.4.24.47 casein + H2O denatured casein, poor substrate Crotalus horridus horridus ?
-
 ?
3.4.24.47 Collagen + H2O poor substrate Crotalus horridus horridus ?
-
 ?
3.4.24.47 Fibrin + H2O thrombin-induced fibrin, hydrolysis of alpha chain Crotalus horridus horridus ?
-
 ?
3.4.24.47 Fibrinogen + H2O hydrolysis of alpha and beta chain Crotalus horridus horridus Hydrolyzed fibrinogen
-
 ?
3.4.24.47 Hemoglobin + H2O poor substrate Crotalus horridus horridus ?
-
 ?
3.4.24.47 Hide powder + H2O from cow, hydrolysis at 20% the rate of cow hide powder azure Crotalus horridus horridus ?
-
 ?
3.4.24.47 hide powder azure + H2O from cow Crotalus horridus horridus ?
-
 ?
3.4.24.47 additional information substrate specificity Crotalus horridus horridus ?
-
 ?
3.4.24.47 additional information no substrates are elastin (as elastin-orcein or elastin-congo red) Crotalus horridus horridus ?
-
 ?
3.4.24.47 additional information no substrates are keratin (as keratin azure) Crotalus horridus horridus ?
-
 ?
3.4.24.47 additional information no substrates are N-carbobenzoxy-Ser-Leu-NH2, N-carbobenzoxy-Ala-Leu-NH2, N-carbobenzoxy-Ile-Gly-NH2, N,N-dimethylcasein, N,N-dimethylhemoglobin or several dipeptides Crotalus horridus horridus ?
-
 ?
3.4.24.47 Oxidized insulin A-chain + H2O cleavage site: Ser12-Leu13 Crotalus horridus horridus Hydrolyzed oxidized insulin A-chain
-
 ?
3.4.24.47 Oxidized insulin B-chain + H2O cleavage site: Ala14-Leu15 Crotalus horridus horridus Hydrolyzed oxidized insulin B-chain
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.47 37
-
 assay at Crotalus horridus horridus