EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.42 | Collagenase inhibitor SC 44463 | - |
Crotalus atrox | |
3.4.24.42 | cysteine | - |
Crotalus atrox | |
3.4.24.42 | EDTA | - |
Crotalus atrox | |
3.4.24.42 | additional information | iodoacetate; no inhibition by aprotinin, PMSF | Crotalus atrox | |
3.4.24.42 | phosphoramidon | weak, isozyme Ht-d | Crotalus atrox | |
3.4.24.42 | thiorphan | - |
Crotalus atrox |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.1 | Zn2+ | zinc metalloproteinase | Crotalus atrox | |
3.4.24.1 | Zn2+ | zinc binding-site | Crotalus atrox | |
3.4.24.42 | Zn2+ | zinc metalloproteinase | Crotalus atrox |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.24.1 | 23230 | - |
Ht-d, amino acid analysis | Crotalus atrox |
3.4.24.42 | additional information | - |
amino acid composition | Crotalus atrox |
3.4.24.42 | additional information | - |
they differ by a single amino acid substitution at position 181, Ala (Cc) or Asp (Cd) | Crotalus atrox |
3.4.24.42 | 23230 | - |
Crotalus atrox, isozyme Ht-d | Crotalus atrox |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.1 | Proteins + H2O | Crotalus atrox | preferential cleavage: -Leu, -Ile, -Val, -Phe | ? | - |
? | |
3.4.24.42 | Basement membranes surrounding capillaries + H2O | Crotalus atrox | involved in disruption of capillary membranes causing hemorrhage in surrounding tissue | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.1 | Crotalus atrox | - |
- |
- |
3.4.24.42 | Crotalus atrox | - |
Western diamondback rattlesnake | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.42 | venom | - |
Crotalus atrox | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.1 | Gelatin + H2O | - |
Crotalus atrox | ? | - |
? | |
3.4.24.1 | additional information | not: interstitial collagen type I and III | Crotalus atrox | ? | - |
? | |
3.4.24.1 | additional information | specificity of Ht-d | Crotalus atrox | ? | - |
? | |
3.4.24.1 | Proteins + H2O | preferential cleavage: -Leu, -Ile, -Val, -Phe | Crotalus atrox | ? | - |
? | |
3.4.24.1 | Type IV collagen + H2O | - |
Crotalus atrox | ? | - |
? | |
3.4.24.42 | 2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzyl amide + H2O | - |
Crotalus atrox | ? | - |
? | |
3.4.24.42 | Basement membranes surrounding capillaries + H2O | involved in disruption of capillary membranes causing hemorrhage in surrounding tissue | Crotalus atrox | ? | - |
? | |
3.4.24.42 | Collagen type IV + H2O | basement membrane component, alpha1 (MW 185000) and alpha2 (MW 170000) chain | Crotalus atrox | Hydrolyzed collagen type IV | MW 170000, MW 164000, MW 125000, MW 110000, MW 940000 and MW 64000 fragments | ? | |
3.4.24.42 | Gelatin of collagen type I + H2O | i.e. denatured collagen | Crotalus atrox | Hydrolyzed gelatin of collagen type I | MW 60000 and MW 50000 fragments | ? | |
3.4.24.42 | Gelatin of collagen type III + H2O | i.e. denatured collagen | Crotalus atrox | ? | - |
? | |
3.4.24.42 | Gelatin of collagen type V + H2O | i.e. denatured collagen, hydrolysis at 38ΓΈC and above, not below | Crotalus atrox | Hydrolyzed gelatin of collagen type V | MW 130000, MW 118000, MW 93000 and MW 85000 fragments | ? | |
3.4.24.42 | additional information | no hydrolysis of interstitial collagen, native type I collagen | Crotalus atrox | ? | - |
? |