EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.40 | benzyloxycarbonyl-D-Ala-Leu-Ala | competitive to benzyloxycarbonyl-Ala-Phe-Gly-Ala | Pseudomonas aeruginosa | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-D-Ala | benzyloxycarbonyl-Ala-Phe-Gly-Ala as substrate | Pseudomonas aeruginosa | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-Gly | benzyloxycarbonyl-Ala-Phe-Gly-Ala as substrate | Pseudomonas aeruginosa | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-NH2 | benzyloxycarbonyl-Ala-Phe-Gly-Ala as substrate | Pseudomonas aeruginosa | |
3.4.24.40 | Benzyloxycarbonyl-Phe-D-Leu-Ala | competitive to benzyloxycarbonyl-Ala-Phe-Gly-Ala | Pseudomonas aeruginosa | |
3.4.24.40 | additional information | diisopropyl phosphofluoridate; PCMB; potato inhibitor; soybean trypsin inhibitor; tosyl-L-Phe chloromethyl ketone or tosyl-L-Lys chloromethyl ketone | Pseudomonas aeruginosa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.24.40 | 0.2 | - |
benzyloxycarbonyl-Phe-Phe-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 0.4 | - |
Benzyloxycarbonyl-Phe-Ala-Ala | benzyloxycarbonyl-Phe-Leu-Ala | Pseudomonas aeruginosa | |
3.4.24.40 | 0.5 | - |
Ala-Ala-Ala-Ala-Ala-Ala | benzyloxycarbonyl-Phe-L-Ala-Ala | Pseudomonas aeruginosa | |
3.4.24.40 | 0.6 | - |
benzyloxycarbonyl-Gly-Leu-Phe | benzyloxycarbonyl-Ala-Phe-Leu-Ala | Pseudomonas aeruginosa | |
3.4.24.40 | 0.9 | - |
Benzyloxycarbonyl-Gly-Leu-Leu | benzyloxycarbonyl-Gly-Phe-Leu-Ala | Pseudomonas aeruginosa | |
3.4.24.40 | 1.2 | - |
Ala-Ala-Ala-Ala-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 1.5 | - |
benzyloxycarbonyl-Ala-Leu-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 1.8 | - |
benzyloxycarbonyl-Phe-Gly-Ala | benzyloxycarbonyl-Phe-Ser-Ala, benzyloxycarbonyl-Leu-Ala-Ala | Pseudomonas aeruginosa | |
3.4.24.40 | 2.3 | - |
benzyloxycarbonyl-Phe-Gly-Leu-Ala | benzyloxycarbonyl-Ala-Leu-Gly-Gly | Pseudomonas aeruginosa | |
3.4.24.40 | 2.4 | - |
benzyloxycarbonyl-Gly-Leu-Gly-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 2.5 | - |
benzyloxycarbonyl-Val-Ala-Ala | benzyloxycarbonyl-Ala-Phe-Gly-Ala | Pseudomonas aeruginosa | |
3.4.24.40 | 2.7 | - |
Benzyloxycarbonyl-Ala-Ala-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 2.9 | - |
Benzyloxycarbonyl-Gly-Leu-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 4.3 | - |
Benzyloxycarbonyl-Gly-Leu-Gly-Gly-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 4.8 | - |
benzyloxycarbonyl-Ala-Gly-Leu-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 5.3 | - |
Benzyloxycarbonyl-Gly-Pro-Gly-Gly-Pro-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 5.4 | - |
benzyloxycarbonyl-Gly-Gly-Leu-Ala | benzyloxycarbonyl-Ala-Gly-Gly-Leu | Pseudomonas aeruginosa | |
3.4.24.40 | 7.7 | - |
Benzyloxycarbonyl-Gly-Ala-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 8.7 | - |
Ala-Ala-Ala-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 11 | - |
Benzyloxycarbonyl-Gly-Leu-Gly-Gly | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 17.3 | - |
Phe-Gly-Leu-Ala | - |
Pseudomonas aeruginosa | |
3.4.24.40 | 20 | - |
benzyloxycarbonyl-D-Ala-Gly-Leu-Ala | - |
Pseudomonas aeruginosa |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.40 | Ca2+ | no activation by added Ca2+ | Pseudomonas aeruginosa | |
3.4.24.40 | Ca2+ | 1-2 gatom/mol enzyme | Pseudomonas aeruginosa | |
3.4.24.40 | Co2+ | activation | Pseudomonas aeruginosa | |
3.4.24.40 | Co2+ | above 5 mM, benzoxycarbonyl-Ala-Phe-Gly-Ala as substrate | Pseudomonas aeruginosa | |
3.4.24.40 | additional information | contains no significant amount of any metal except Ca2+ | Pseudomonas aeruginosa | |
3.4.24.40 | additional information | no activation by Mn2+ | Pseudomonas aeruginosa | |
3.4.24.40 | additional information | no activation by Ni2+ | Pseudomonas aeruginosa | |
3.4.24.40 | Zn2+ | zinc-containing metalloproteinase (not) | Pseudomonas aeruginosa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.24.40 | 48400 | - |
Pseudomonas aeruginosa, sedimentation velocity centrifugation | Pseudomonas aeruginosa |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.40 | Pseudomonas aeruginosa | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.40 | Benzyloxycarbonyl tripeptides + H2O | overview | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Ala-Ala-Ala + H2O | cleavage site: AlaÄ+ÄAla-Ala | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Ala-Gly-Gly-Leu-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Ala-Gly-Gly-Leu-Xaa + H2O | a hydrophobic or bulky residue at P3' results in marked increase in hydrolysis | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | benzyloxycarbonyl-Ala-Gly-Leu-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | benzyloxycarbonyl-Ala-Leu-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | benzyloxycarbonyl-D-Ala-Gly-Leu-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Ala-Ala + H2O | cleavage site: Gly-Ala | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Gly-Gly-Leu + H2O | poor substrate | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Gly-Leu amide + H2O | poor substrate | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | benzyloxycarbonyl-Gly-Gly-Leu-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | benzyloxycarbonyl-Gly-Leu-Gly-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-Gly-Gly + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-Gly-Gly-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-Gly-Gly-Xaa + H2O | a hydrophobic or bulky residue at P3' results in marked increase in hydrolysis | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-Leu + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-Phe + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Leu-Xaa + H2O | at position Xaa with decreasing susceptibility to the enzyme: Leu, Phe or Ala, poor substrates: Gly or NH2, D-Ala | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Gly-Pro-Gly-Gly-Pro-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Phe-Ala-Ala + H2O | cleavage site: Phe-Ala | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | benzyloxycarbonyl-Phe-Gly-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | benzyloxycarbonyl-Phe-Gly-Leu-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Phe-Leu-Ala-Ala + H2O | best substrate | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | benzyloxycarbonyl-Phe-Phe-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Phe-Xaa-Ala + H2O | susceptibility to the enzyme is Xaa-dependent, in decreasing order of efficiency: Ala, Phe, Leu, Trp or Ser or Gly | Pseudomonas aeruginosa | Benzyloxycarbonyl-Phe + Xaa-Ala | - |
? | |
3.4.24.40 | benzyloxycarbonyl-Val-Ala-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Xaa-Ala-Ala + H2O | susceptibility to the enzyme is Xaa-dependent, in decreasing order of efficiency: L-Phe, Leu or Ala, Val, Gly, D-Ala | Pseudomonas aeruginosa | Benzyloxycarbonyl-Xaa + Ala-Ala | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Xaa-Gly-Leu-Ala + H2O | a hydrophobic or bulky residue at P2 results in marked increase in hydrolysis | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Xaa-Leu-Ala + H2O | susceptibility to the enzyme is Xaa-dependent, in decreasing order of efficiency: L-Phe, Leu or Ala, Val, Gly, D-Ala | Pseudomonas aeruginosa | Benzyloxycarbonyl-Xaa + Leu-Ala | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Xaa-Phe-Gly-Ala + H2O | a hydrophobic or bulky residue at P2 results in marked increase in hydrolysis | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Benzyloxycarbonyl-Xaa-Phe-Leu-Ala + H2O | a hydrophobic or bulky residue at P2 results in marked increase in hydrolysis | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | L-Ala-L-Ala-L-Ala-L-Ala + H2O | - |
Pseudomonas aeruginosa | L-Ala-L-Ala + L-Ala-L-Ala | - |
? | |
3.4.24.40 | L-Ala-L-Ala-L-Ala-L-Ala-L-Ala + H2O | - |
Pseudomonas aeruginosa | L-Ala-L-Ala + L-Ala-L-Ala-L-Ala | - |
? | |
3.4.24.40 | L-Ala-L-Ala-L-Ala-L-Ala-L-Ala-L-Ala + H2O | - |
Pseudomonas aeruginosa | L-Ala-L-Ala-L-Ala + L-Ala-L-Ala-L-Ala | - |
? | |
3.4.24.40 | L-Ala-oligopeptides + H2O | proteolytic activity increases drastically with increasing chain length from tetramer to hexamer, no substrate: dipeptide or tripeptide | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | additional information | elastin | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | additional information | tetrapeptides are poorer substrates than benzyloxycarbonyl tetrapeptides | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | additional information | benzyloxycarbonyl dipeptides, N-acetylated amino acid esters or amides, dipeptide amides, tripeptides, benzyloxycarbonyl-(Gly)4, benzyloxycarbonyl-(Gly)5, benzyloxycarbonyl-Gly-Leu-Gly-Gly-D-Ala | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Oxidized insulin B-chain + H2O | cleavage sites | Pseudomonas aeruginosa | ? | - |
? | |
3.4.24.40 | Phe-Gly-Leu-Ala + H2O | - |
Pseudomonas aeruginosa | ? | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.24.40 | additional information | - |
pI: 4 | Pseudomonas aeruginosa |
3.4.24.40 | 7 | - |
benzyloxycarbonyl-Phe-Ala-Ala or benzyloxycarbonyl-Ala-Phe-Gly-Ala as substrate | Pseudomonas aeruginosa |