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Literature summary extracted from

  • Wilhelm, S.M.; Collier, I.E.; Marmer, B.L.; Eisen, A.Z.; Grant, G.A.; Goldberg, G.I.
    SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages [published erratum appears in J Biol Chem 1990 Dec 25;265(36):22570] (1989), J. Biol. Chem., 264, 17213-17221.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.35
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.35 extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.35 84000
-
 1 * 92000, human SC40-transformed lung cells, proenzyme, SDS-PAGE, 1 * 84000, human SC40-transformed lung cells, activated form, SDS-PAGE Homo sapiens
3.4.24.35 92000
-
 human SC40-transformed lung cells, gel filtration, glycosylated proenzyme can be activated by organomercurials by removal of 73 amino acids Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.35 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.35 glycoprotein
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.35 SC40-transformed cells Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.35 culture medium contitioned culture medium Homo sapiens
-
3.4.24.35 culture medium from SC40-transformed cells, normal alveolar macrophages, phorbol ester-differentiated monocytic leukemia U937 cells, fibrosarcoma HT1080 cells, cultured keratinocytes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.35 Collagen + H2O type IV (native) Homo sapiens ?
-
 ?
3.4.24.35 Collagen + H2O type V (native) Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.35 monomer 1 * 92000, human SC40-transformed lung cells, proenzyme, SDS-PAGE, 1 * 84000, human SC40-transformed lung cells, activated form, SDS-PAGE Homo sapiens