Literature summary extracted from

Fridman, R.; Bird, R.E.; Hoyhta, M.; Oelkuct, M.; Komarek, D.; Liang, C.M.; Berman, M.L.; Liotta, L.A.; Stetler-Stevenson, W.G.; Fuerst, T.R.
Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme (1993), Biochem. J., 289, 411-416.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.24	Tissue inhibitor of metalloproteinase-2	TIMP-2, not only a potent inhibitor of the activated enzyme but also prevents the generation of low-molecular-mass species and full enzymic activity from the zymogen	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.24.24	extracellular	-	Homo sapiens	-	-

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.4.24.24	62000	-	x * 62000, human, active enzyme, SDS-PAGE under reducing conditions	Homo sapiens
3.4.24.24	72000	-	x * 72000, human, zymogen, SDS-PAGE under reducing conditions	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.24	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.4.24.24	-	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.24	culture medium	from HeLa cells co-infected with each of the recombinant Vaccinia viruses and with vTF7-3	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.24	Collagen + H2O	-	Homo sapiens	?	-	?
3.4.24.24	Gelatin + H2O	-	Homo sapiens	?	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.4.24.24	?	x * 62000, human, active enzyme, SDS-PAGE under reducing conditions	Homo sapiens
3.4.24.24	?	x * 72000, human, zymogen, SDS-PAGE under reducing conditions	Homo sapiens

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Release 2023.1 (January 2023)