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Literature summary extracted from

  • Yamaguchi, T.; Fukase, M.; Sugimoto, T.; Kido, H.; Chihara, K.
    Purification of meprin from human kidney and its role in parathyroid hormone degradation (1994), Biol. Chem. Hoppe-Seyler, 375, 821-824.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.18 1,10-phenanthroline
-
 Homo sapiens
3.4.24.18 chymostatin
-
 Homo sapiens
3.4.24.18 DTT strong Homo sapiens
3.4.24.18 EDTA
-
 Homo sapiens
3.4.24.18 EGTA
-
 Homo sapiens
3.4.24.18 GSH
-
 Homo sapiens
3.4.24.18 additional information inhibitors of elastase, aminopeptidase, serine, aspartic or cysteic proteases; no inhibition by phosphoramidon Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.18 membrane
-
 Homo sapiens 16020
-
3.4.24.18 microvillus
-
 Homo sapiens 5902
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.18 91000
-
 2 * 91000, human, SDS-PAGE, reducing conditions Homo sapiens
3.4.24.18 200000
-
 human, SDS-PAGE, non-reducing conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.18 Parathyroid hormone + H2O Homo sapiens involved in PTH-degradation in human kidney ?
-
 ?
3.4.24.18 Parathyroid hormone + H2O Homo sapiens PPH involved in PTH-degradation in human kidney ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.18 Homo sapiens
-
 PPH
-
3.4.24.18 Homo sapiens PPH
-
 PPH
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.18 to near homogeneity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.18 kidney
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.18 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.18 Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 8.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 8.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens PPH ?
-
 ?
3.4.24.18 Benzyloxycarbonyl-Glu-Lys-Lys 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 9.1% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 3.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 3.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens PPH ?
-
 ?
3.4.24.18 Benzyloxycarbonyl-Val-Leu-Lys 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 10.4% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 Glutaryl-Phe 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 2.4% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 6.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 additional information poor substrates are compounds with 3 or less amino acids Homo sapiens ?
-
 ?
3.4.24.18 additional information poor substrates are compounds with 3 or less amino acids Homo sapiens PPH ?
-
 ?
3.4.24.18 Parathyroid hormone + H2O involved in PTH-degradation in human kidney Homo sapiens ?
-
 ?
3.4.24.18 Parathyroid hormone + H2O involved in PTH-degradation in human kidney Homo sapiens PPH ?
-
 ?
3.4.24.18 Parathyroid hormone + H2O i.e. hPTH-(1-84), in vivo and in vitro Homo sapiens Hydrolyzed parathyroid hormone
-
 ?
3.4.24.18 Succinyl-Ala-Ala-Pro-Phe 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 9% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 Succinyl-Ala-Pro-Ala 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 2.8% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 Succinyl-Gly-Pro 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 10.7% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.18 Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens PPH ?
-
 ?
3.4.24.18 Succinyl-Leu-Tyr 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 5.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
3.4.24.18 Tyr 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 3.3% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.18 dimer 2 * 91000, human, SDS-PAGE, reducing conditions Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.18 37
-
 assay at Homo sapiens