EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.18 | additional information | hippuryl-His-Leu, His-Leu, benzamidine; soybean trypsin inhibitor | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.24.11 | 0.032 | - |
Substance P | - |
Rattus norvegicus | |
3.4.24.11 | 0.092 | - |
bradykinin | - |
Rattus norvegicus | |
3.4.24.11 | 0.755 | - |
Luteinizing hormone-releasing hormone | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.18 | membrane | - |
Rattus norvegicus | 16020 | - |
3.4.24.18 | microvillus | - |
Rattus norvegicus | 5902 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.11 | Atrial natriuretic factor + H2O | Rattus norvegicus | dominant enzyme in the hydrolysis of atrial natriuretic factor | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.11 | Rattus norvegicus | - |
- |
- |
3.4.24.18 | Rattus norvegicus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.24.18 | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.11 | kidney | - |
Rattus norvegicus | - |
3.4.24.18 | kidney | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.11 | angiotensin I + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | angiotensin II + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | angiotensin III + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Atrial natriuretic factor + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Atrial natriuretic factor + H2O | dominant enzyme in the hydrolysis of atrial natriuretic factor | Rattus norvegicus | ? | - |
? | |
3.4.24.11 | bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Luteinizing hormone-releasing hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | oxytocin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Substance P + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.18 | angiotensin I + H2O | i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu, cleavage site: Tyr-Ile | Rattus norvegicus | Asp-Arg-Val-Tyr + Ile-His-Pro-Phe + Ile-His-Pro-Phe-His-Leu | - |
? | |
3.4.24.18 | angiotensin II + H2O | poor substrate | Rattus norvegicus | Asp-Arg-Val-Tyr + Ile-His-Pro-Phe | - |
? | |
3.4.24.18 | angiotensin III + H2O | poor substrate | Rattus norvegicus | Arg-Val-Tyr + Ile-His-Pro-Phe | - |
? | |
3.4.24.18 | angiotensin III + H2O | i.e. Arg-Val-Tyr-Ile-His-Pro-Phe, cleavage site: Tyr-Ile | Rattus norvegicus | Arg-Val-Tyr + Ile-His-Pro-Phe | - |
? | |
3.4.24.18 | bradykinin + H2O | one cleavage site: Phe-Ser (major cleavage site) | Rattus norvegicus | Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg | - |
? | |
3.4.24.18 | bradykinin + H2O | one cleavage site: Phe-Ser | Rattus norvegicus | Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg | - |
? | |
3.4.24.18 | bradykinin + H2O | minor cleavage site: Gly-Phe | Rattus norvegicus | Arg-Pro-Pro-Gly + Phe-Ser-Pro-Phe-Arg | - |
? | |
3.4.24.18 | Human alpha-atrial natiuretic peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.18 | Insulin B-chain + H2O | I125-iodinated | Rattus norvegicus | Hydrolyzed insulin B-chain | - |
? | |
3.4.24.18 | Luliberin + H2O | i.e. luteinizing-hormone releasing hormone, preferred cleavage site: Trp3-Ser4, other sites are Ser4-Tyr5 and Tyr5-Gly6 | Rattus norvegicus | ? | - |
? | |
3.4.24.18 | additional information | hydrolysis occurs on carboxy side of aromatic residues | Rattus norvegicus | ? | - |
? | |
3.4.24.18 | additional information | insulin, [Arg8]-vasopressin, cytochrome c, ovalbumin, serum albumin | Rattus norvegicus | ? | - |
? | |
3.4.24.18 | Substance P + H2O | cleavage sites: Glu6-Phe7, Phe7-Phe8, Phe8-Gly9 | Rattus norvegicus | Hydrolyzed substance P | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.24.18 | 37 | - |
assay at | Rattus norvegicus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.24.11 | 14 | - |
Luteinizing hormone-releasing hormone | - |
Rattus norvegicus | |
3.4.24.11 | 84.3 | - |
Substance P | - |
Rattus norvegicus | |
3.4.24.11 | 106 | - |
bradykinin | - |
Rattus norvegicus |