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Literature summary extracted from

  • Morihara, K.; Tsuzuki, H.; Murao, S.; Oda, K.
    Pepstatin-insenstive acid proteases from Scytalidium lignicolum. Kinetic study with synthetic peptides (1979), J. Biochem., 85, 661-668.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.31 Ac-pepstatin benzyloxycarbonyl-Gly-Leu-Ala-Ala as substrate Scytalidium lignicola
3.4.23.31 Benzyloxycarbonyl-Gly-Pro-Phe-Leu-Ala benzyloxycarbonyl-Gly-Leu-Ala-Ala as substrate Scytalidium lignicola
3.4.23.31 benzyloxycarbonyl-Phe benzyloxycarbonyl-Gly-Leu-Ala-Ala as substrate Scytalidium lignicola
3.4.23.31 Benzyloxycarbonyl-Phe-D-Leu-Ala-Ala benzyloxycarbonyl-Gly-Leu-Ala-Ala as substrate Scytalidium lignicola
3.4.23.31 Benzyloxycarbonyl-Phe-Leu benzyloxycarbonyl-Gly-Leu-Ala-Ala as substrate Scytalidium lignicola
3.4.23.31 Benzyloxycarbonyl-Phe-Leu-Ala benzyloxycarbonyl-Gly-Leu-Ala-Ala as substrate Scytalidium lignicola
3.4.23.31 additional information a related enzyme from the same organism, proteinase C is also insensitive to these inhibitors; pepstatin Scytalidium lignicola
3.4.23.32 additional information methyl 2-diazoacetamidohexanoate; not: pepstatin Scytalidium lignicola

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.23.31 additional information
-
 additional information kinetic studies with synthetic peptides Scytalidium lignicola
3.4.23.31 0.6
-
 Benzyloxycarbonyl-Ala-Phe-Leu-Ala
-
 Scytalidium lignicola
3.4.23.31 0.8
-
 benzyloxycarbonyl-Phe-Lys-Ala-Ala
-
 Scytalidium lignicola
3.4.23.31 1
-
 Succinyl-Phe-Arg-Ala-Phe 4-nitrophenyl ester benzyloxycarbonyl-Phe-Leu-Ala-Ala, benzyloxycarbonyl-Ala-Ala-Lys-Ala-Ala-Ala Scytalidium lignicola
3.4.23.31 1.1
-
 Benzyloxycarbonyl-Ala-Leu-Ala-Ala
-
 Scytalidium lignicola
3.4.23.31 1.3
-
 Benzyloxycarbonyl-Gly-Phe-Leu-Ala
-
 Scytalidium lignicola
3.4.23.31 1.5
-
 Benzyloxycarbonyl-Ala-Phe-Gly-Ala
-
 Scytalidium lignicola
3.4.23.31 1.6
-
 Benzyloxycarbonyl-Phe-Tyr-Ala-Ala
-
 Scytalidium lignicola
3.4.23.31 2.1
-
 Benzyloxycarbonyl-Lys-Leu-Ala-Ala
-
 Scytalidium lignicola
3.4.23.31 2.5
-
 Benzyloxycarbonyl-Lys-Ala-Ala-Ala
-
 Scytalidium lignicola
3.4.23.31 3.1
-
 Benzyloxycarbonyl-Ala-Lys-Ala-Ala-Ala
-
 Scytalidium lignicola
3.4.23.31 3.7
-
 benzyloxycarbonyl-Phe-Glu-Ala-Ala
-
 Scytalidium lignicola

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.31 Scytalidium lignicola
-
 A-2
-
3.4.23.31 Scytalidium lignicola
-
 enzyme form: A-1
-
3.4.23.31 Scytalidium lignicola
-
 ATCC 24568
-
3.4.23.31 Scytalidium lignicola A-2
-
 A-2
-
3.4.23.32 Scytalidium lignicola
-
 ATCC 24568
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.31 Benzyloxycarbonyl-Ala-Ala-Lys-Ala-Ala-Ala + H2O
-
 Scytalidium lignicola Benzyloxycarbonyl-Ala-Ala-Lys + Ala-Ala-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Ala-Ala-Lys-Ala-Ala-Ala + H2O
-
 Scytalidium lignicola A-2 Benzyloxycarbonyl-Ala-Ala-Lys + Ala-Ala-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Ala-Leu-Ala-Ala + H2O
-
 Scytalidium lignicola Benzyloxycarbonyl-Ala-Leu + Ala-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Ala-Lys-Ala-Ala-Ala + H2O
-
 Scytalidium lignicola Benzyloxycarbonyl-Ala-Lys + Ala-Ala-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Ala-Lys-Ala-Ala-Ala + H2O
-
 Scytalidium lignicola A-2 Benzyloxycarbonyl-Ala-Lys + Ala-Ala-Ala
-
 ?
3.4.23.31 benzyloxycarbonyl-Ala-Phe-Gly-Ala + H2O
-
 Scytalidium lignicola benzyloxycarbonyl-Ala-Phe + Gly-Ala
-
 ?
3.4.23.31 benzyloxycarbonyl-Ala-Phe-Leu-Ala + H2O
-
 Scytalidium lignicola benzyloxycarbonyl-Ala-Phe + Leu-Ala
-
 ?
3.4.23.31 benzyloxycarbonyl-Gly-Phe-Leu-Ala + H2O
-
 Scytalidium lignicola benzyloxycarbonyl-Gly-Phe + Leu-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Leu-Ala-Ala + H2O slow hydrolysis Scytalidium lignicola Benzyloxycarbonyl-Leu + Ala-Ala
-
 ?
3.4.23.31 benzyloxycarbonyl-Lys-Ala-Ala-Ala + H2O
-
 Scytalidium lignicola benzyloxycarbonyl-Lys-Ala + Ala-Ala
-
 ?
3.4.23.31 benzyloxycarbonyl-Lys-Leu-Ala-Ala + H2O
-
 Scytalidium lignicola benzyloxycarbonyl-Lys-Leu + Ala-Ala
-
 ?
3.4.23.31 benzyloxycarbonyl-Phe-Glu-Ala-Ala + H2O
-
 Scytalidium lignicola benzyloxycarbonyl-Phe-Glu + Ala-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Phe-Leu-Ala + H2O slow hydrolysis Scytalidium lignicola Benzyloxycarbonyl-Phe + Leu-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Phe-Leu-Ala-Ala + H2O
-
 Scytalidium lignicola ?
-
 ?
3.4.23.31 Benzyloxycarbonyl-Phe-Leu-Ala-Ala + H2O
-
 Scytalidium lignicola A-2 ?
-
 ?
3.4.23.31 Benzyloxycarbonyl-Phe-Leu-Ala-Ala + H2O
-
 Scytalidium lignicola Benzyloxycarbonyl-Phe-Leu + Ala-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Phe-Leu-Ala-Ala + H2O
-
 Scytalidium lignicola A-2 Benzyloxycarbonyl-Phe-Leu + Ala-Ala
-
 ?
3.4.23.31 benzyloxycarbonyl-Phe-Lys-Ala-Ala + H2O
-
 Scytalidium lignicola benzyloxycarbonyl-Phe-Lys + Ala-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Phe-Tyr-Ala + H2O slow Scytalidium lignicola Benzyloxycarbonyl-Phe + Tyr-Ala
-
 ?
3.4.23.31 Benzyloxycarbonyl-Phe-Tyr-Ala-Ala + H2O
-
 Scytalidium lignicola Benzyloxycarbonyl-Phe-Tyr + Ala-Ala
-
 ?
3.4.23.31 Succinyl-Phe-Arg-Ala-Phe 4-nitrophenyl ester + H2O
-
 Scytalidium lignicola ?
-
 ?
3.4.23.31 Succinyl-Phe-Arg-Ala-Phe 4-nitrophenyl ester + H2O
-
 Scytalidium lignicola A-2 ?
-
 ?
3.4.23.32 Benzyloxycarbonyl-Ala-Ala-Lys-Ala-Ala-Ala + H2O slow hydrolysis Scytalidium lignicola Benzyloxycarbonyl-Ala-Ala-Lys + Ala-Ala-Ala
-
 ?
3.4.23.32 Benzyloxycarbonyl-Ala-Lys-Ala-Ala-Ala + H2O slow hydrolysis Scytalidium lignicola Benzyloxycarbonyl-Ala-Lys + Ala-Ala-Ala
-
 ?
3.4.23.32 Benzyloxycarbonyl-Lys-Leu-Ala-Ala + H2O slow hydrolysis Scytalidium lignicola Benzyloxycarbonyl-Lys-Leu-Ala + Ala
-
 ?
3.4.23.32 Benzyloxycarbonyl-Phe-Leu-Ala-Ala + H2O slow hydrolysis Scytalidium lignicola Benzyloxycarbonyl-Phe-Leu-Ala + Ala
-
 ?
3.4.23.32 Benzyloxycarbonyl-Phe-Tyr-Ala-Ala + H2O slow hydrolysis Scytalidium lignicola Benzyloxycarbonyl-Phe-Tyr-Ala + Ala
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.23.31 3.6
-
 benzyloxycarbonyl-Phe-Glu-Ala-Ala, enzyme form A-1 and A-2 Scytalidium lignicola