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Literature summary extracted from

  • Azaryan, A.V.; Wong, M.; Friedman, T.C.; Cawley, N.X.; Estivariz, F.E.; Chen, H-C.; Loh, Y.P.
    Purification and characterization of a paired basic residue-specific yeast aspartic protease encoded by the YAP3 gene. Similarity to the mammalian pro-opiomelanocortin-converting enzyme (1993), J. Biol. Chem., 268, 11968-11975.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.23.17 DTT 1 mM, stimulates 1.3fold Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.17 pepstatin A
-
 Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.23.17 Ca2+ 5 mM, stimulates Saccharomyces cerevisiae
3.4.23.17 Ca2+ 1.4fold Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.23.17 68000
-
 gel filtration Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.17 Saccharomyces cerevisiae
-
 overexpressing BJ 3501 strain
-
3.4.23.17 Saccharomyces cerevisiae BJ 3501
-
 overexpressing BJ 3501 strain
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.23.17 glycoprotein
-
 Saccharomyces cerevisiae

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.17 overexpressing BJ 3501 strain Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.17 Human beta-lipotropin + H2O
-
 Saccharomyces cerevisiae More beta-endorphin(1-31) + beta-endorphin(1-29) + beta-endorphin(1-28) + gamma-lipotropin + beta-melanocyte-stimulating hormone ?
3.4.23.17 Human beta-lipotropin + H2O
-
 Saccharomyces cerevisiae BJ 3501 More beta-endorphin(1-31) + beta-endorphin(1-29) + beta-endorphin(1-28) + gamma-lipotropin + beta-melanocyte-stimulating hormone ?
3.4.23.17 NH2-terminal pro-opiomelanocortin1-77 + H2O
-
 Saccharomyces cerevisiae Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
 ?
3.4.23.17 NH2-terminal pro-opiomelanocortin1-77 + H2O
-
 Saccharomyces cerevisiae BJ 3501 Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
 ?
3.4.23.17 Pro-opiomelanocortin + H2O
-
 Saccharomyces cerevisiae Adrenocorticotropin + beta-lipotropin
-
 ?
3.4.23.17 Pro-opiomelanocortin + H2O
-
 Saccharomyces cerevisiae BJ 3501 Adrenocorticotropin + beta-lipotropin
-
 ?
3.4.23.17 Small synthetic peptides with paired basic residues + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
3.4.23.17 Small synthetic peptides with paired basic residues + H2O
-
 Saccharomyces cerevisiae BJ 3501 ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.23.17 4 4.5
-
 Saccharomyces cerevisiae