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Literature summary extracted from

  • Estivariz, F.E.; Birch, N.P.; Loh, Y.P.
    Generation of Lys-gamma 3-melanotropin from pro-opiomelanocortin 1-77 by a bovine intermediate lobe secretory vesicle membrane-associated aspartic protease and purified pro-opiomelanocortin converting enzyme (1989), J. Biol. Chem., 264, 17796-17801.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.17 membrane
-
 Bos taurus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.23.17 Ca2+ 5 mM, stimulates Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.17 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.17 hypophysis intermediate Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.17 NH2-terminal pro-opiomelanocortin1-77 + H2O preferential cleavage between Arg49-Lys50 Bos taurus Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49 + gamma-melanotropin, minor product ?
3.4.23.17 Pro-opiomelanocortin + H2O
-
 Bos taurus Adrenocorticotropin + beta-lipotropin
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.23.17 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.23.17 4 5
-
 Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.23.17 3 6 6: 10% of activity maximum Bos taurus
3.4.23.17 3 6 3: about 15% of activity maximum Bos taurus