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Literature summary extracted from
- The proteolytic activities of chymopapain, papain, and papaya proteinase III (1985), Biochim. Biophys. Acta, 828, 196-204.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.6 | albumin | inhibits hydrolysis of synthetic substrates | Carica papaya | |
| 3.4.22.6 | Succinyl-albumin | inhibits hydrolysis of synthetic substrates | Carica papaya | |
| 3.4.22.30 | Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide | competitive to succinyl-albumin | Carica papaya |  |
| 3.4.22.30 | Succinyl-albumin | competitive to benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide | Carica papaya |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.22.6 | 0.000131 | - |
Succinyl-albumin | - |
Carica papaya | |
| 3.4.22.6 | 0.0025 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide | - |
Carica papaya | |
| 3.4.22.30 | 0.000096 | - |
Succinyl-albumin | - |
Carica papaya | |
| 3.4.22.30 | 0.0067 | - |
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide | - |
Carica papaya | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.6 | Carica papaya | - |
- |
- |
| 3.4.22.30 | Carica papaya | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.6 | latex | of unripe fruit | Carica papaya | - |
| 3.4.22.30 | latex | - |
Carica papaya | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.6 | Albumin + H2O | - |
Carica papaya | ? | - |
? | |
| 3.4.22.6 | azocasein + H2O | - |
Carica papaya | ? | - |
? | |
| 3.4.22.6 | benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Carica papaya | benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide | - |
? | |
| 3.4.22.6 | succinyl-albumin | - |
Carica papaya | ? | - |
? | |
| 3.4.22.30 | Albumin + H2O | low activity | Carica papaya | ? | - |
? | |
| 3.4.22.30 | azocasein + H2O | - |
Carica papaya | ? | - |
? | |
| 3.4.22.30 | Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O | - |
Carica papaya | ? | - |
? | |
| 3.4.22.30 | Bovine nasal cartilage + H2O | - |
Carica papaya | ? | - |
? | |
| 3.4.22.30 | Succinyl-albumin + H2O | - |
Carica papaya | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.22.6 | 2.9 | - |
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide | - |
Carica papaya | |
| 3.4.22.6 | 4 | - |
Succinyl-albumin | - |
Carica papaya | |
| 3.4.22.30 | 2.6 | - |
Succinyl-albumin | - |
Carica papaya | |
| 3.4.22.30 | 7.1 | - |
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide | - |
Carica papaya | |
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