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Literature summary extracted from

  • Moore, W.R.
    The purification and properties of cancer procoagulant from murine tumors (1992), Biochem. Biophys. Res. Commun., 184, 819-824.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.26 (D)-Phe-Pro-(D,L)-(4'-guanidino)-Phe-trifluoromethyl ketone
-
 Mus musculus
3.4.22.26 (D)-Phe-Pro-(D,L)-Lys-trifluoromethyl ketone weak Mus musculus
3.4.22.26 (D)-Phe-Pro-Arg-chloromethyl ketone
-
 Mus musculus
3.4.22.26 2-Vinylpyridine
-
 Mus musculus
3.4.22.26 benzoxycarbonyl-Lys-CHN2
-
 Mus musculus
3.4.22.26 HgCl2 Hg2+ Mus musculus
3.4.22.26 iodoacetamide
-
 Mus musculus
3.4.22.26 leupeptin
-
 Mus musculus
3.4.22.26 additional information no inhibition by cystamine, benzoxycarbonyl-Val-Phe Mus musculus
3.4.22.26 N-benzyloxycarbonyl-Phe-Ala-CHN2
-
 Mus musculus
3.4.22.26 phenylmethylsulfonyl fluoride
-
 Mus musculus
3.4.22.26 trans-epoxysuccinyl-L-leucyl-amido(4-guanidino)butane i.e. E-64, thiol protease inhibitor, factor X protects Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.26 cell surface loosely anchored on outside of cells Mus musculus 9986
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.26 Ca2+
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.26 10000
-
 mouse, Lewis lung tumor, gel filtration, procoagulant interacts with Sephacryl-200 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.26 factor X + H2O Mus musculus thiol protease with thrombin-like specificity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.26 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.26 from Lewis lung tumor cells Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.26 amelanotic melanoma cell amelanotic tumor (F10 and B16, mouse) Mus musculus
-
3.4.22.26 B-16 cell
-
 Mus musculus
-
3.4.22.26 carcinoma cell
-
 Mus musculus
-
3.4.22.26 Lewis lung carcinoma cell
-
 Mus musculus
-
3.4.22.26 additional information unique in tumor Mus musculus
-

Storage Stability

EC Number Storage Stability Organism
3.4.22.26 4°C, inactivation within 1 week Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.26 (D)-Leu-(L)-Ser-(L)-Thr-(L)-Arg p-nitroanilide + H2O
-
 Mus musculus ?
-
 ?
3.4.22.26 Factor X + H2O
-
 Mus musculus Factor Xa + ?
-
 ?
3.4.22.26 factor X + H2O thiol protease with thrombin-like specificity Mus musculus ?
-
 ?
3.4.22.26 thrombin TH + H2O
-
 Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.26 monomer mouse, Lewis lung tumor, SDS-PAGE Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.26 37
-
 assay at Mus musculus