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Literature summary extracted from
- Granzyme B (1994), Methods Enzymol., 244, 80-87.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.79 | antipain | - |
Homo sapiens |  |
| 3.4.21.79 | antipain | - |
Mus musculus | |
| 3.4.21.79 | benzamidine | - |
Homo sapiens | |
| 3.4.21.79 | benzamidine | - |
Mus musculus | |
| 3.4.21.79 | Bovine aprotinin | - |
Homo sapiens | |
| 3.4.21.79 | Bovine aprotinin | - |
Mus musculus | |
| 3.4.21.79 | chymostatin | - |
Homo sapiens | |
| 3.4.21.79 | chymostatin | - |
Mus musculus | |
| 3.4.21.79 | Human plasma alpha1-protease inhibitor | - |
Homo sapiens | |
| 3.4.21.79 | Human plasma alpha1-protease inhibitor | - |
Mus musculus | |
| 3.4.21.79 | Human plasma alpha2-protease macroglobulin | - |
Homo sapiens | |
| 3.4.21.79 | Human plasma alpha2-protease macroglobulin | - |
Mus musculus | |
| 3.4.21.79 | Lima-bean trypsin inhibitor | - |
Homo sapiens | |
| 3.4.21.79 | Lima-bean trypsin inhibitor | - |
Mus musculus | |
| 3.4.21.79 | phosphoramidon | - |
Homo sapiens | |
| 3.4.21.79 | phosphoramidon | - |
Mus musculus | |
| 3.4.21.79 | Soybean trypsin inhibitor | - |
Homo sapiens | |
| 3.4.21.79 | Soybean trypsin inhibitor | - |
Mus musculus |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.79 | CaCl2 | 50 mM, enhances Nalpha-tert-butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl esterase activity | Mus musculus | |
| 3.4.21.79 | CaCl2 | 50 mM, enhances Nalpha-tert-butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl esterase activity | Homo sapiens | |
| 3.4.21.79 | NaCl | 0.1-1.0 M, highest activity with Nalpha-tert-butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester | Mus musculus | |
| 3.4.21.79 | NaCl | 0.1-1.0 M, highest activity with Nalpha-tert-butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.79 | Homo sapiens | - |
- |
- |
| 3.4.21.79 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.79 | - |
Mus musculus |
| 3.4.21.79 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.79 | cytotoxic T-lymphocyte cell line | of activated CTL lines, grown in the presence of recombinant interleukin 2 | Mus musculus | - |
| 3.4.21.79 | cytotoxic T-lymphocyte cell line | of activated CTL lines, grown in the presence of recombinant interleukin 2 | Homo sapiens | - |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.4.21.79 | -20°C, pH 4.5, stable for more than 6 months | Mus musculus |
| 3.4.21.79 | -20°C, pH 4.5, stable for more than 6 months | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.79 | Glutamyl 2-naphthylamide + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.79 | Glutamyl 2-naphthylamide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.79 | additional information | preference for substrates with Glu or Asp as the residue amino-terminal to the scissile bond, little or no activity with oligopeptide substrates for trypsin-like, chymotrypsin-like, and elastase-like proteases | Mus musculus | ? | - |
? | |
| 3.4.21.79 | additional information | preference for substrates with Glu or Asp as the residue amino-terminal to the scissile bond, little or no activity with oligopeptide substrates for trypsin-like, chymotrypsin-like, and elastase-like proteases | Homo sapiens | ? | - |
? | |
| 3.4.21.79 | Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.79 | Nalpha-tert-Butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.79 | Nalpha-tert-Butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl ester + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.79 | Nalpha-tert-Butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.79 | 7 | 7.5 | Nalpha-tert-butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl ester | Mus musculus |
| 3.4.21.79 | 7 | 7.5 | Nalpha-tert-butyloxycarbonyl-L-Ala-L-Ala-L-Asp thiobenzyl ester | Homo sapiens |
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