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Literature summary extracted from

  • Simon, M.M.; Hoschutzky, H.; Fruth, U.; Simon, H.G.; Kramer, M.D.
    Purification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytes (1986), EMBO J., 5, 3267-3274.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.78
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.78 3-aminobenzamidine
-
 Mus musculus
3.4.21.78 4-aminobenzamidine
-
 Mus musculus
3.4.21.78 Aprotinin
-
 Mus musculus
3.4.21.78 diisopropyl fluorophosphate
-
 Mus musculus
3.4.21.78 leupeptin
-
 Mus musculus
3.4.21.78 additional information not: inhibitors of either thiol-, metallo- or carboxyl-proteinases Mus musculus
3.4.21.78 phenylmethanesulfonyl fluoride
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.78 30000
-
 x * 60000, mouse, SDS-PAGE under nonreducing condition, x * 30000, SDS-PAGE under reducing condition, mouse Mus musculus
3.4.21.78 60000
-
 x * 60000, mouse, SDS-PAGE under nonreducing condition, x * 30000, SDS-PAGE under reducing condition, mouse Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.78 additional information Mus musculus TSP-1 has the capacity to stimulate B lymphocytes for proliferation in the absence of antigen ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.78 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.78
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.78 T-lymphocyte
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.78 additional information
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.78 D-Pro-Phe-Arg 4-nitroanilide + H2O low or no activity against peptide synthetic substrates carrying other amino acid sequences at position P2, P3 adjacent to L-arginine or against substrates in which amino acids other than L-arginine are bound to the nitroanilide group Mus musculus D-Pro-Phe-Arg + 4-nitroaniline
-
 ?
3.4.21.78 additional information TSP-1 has the capacity to stimulate B lymphocytes for proliferation in the absence of antigen Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.78 ? x * 60000, mouse, SDS-PAGE under nonreducing condition, x * 30000, SDS-PAGE under reducing condition, mouse Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.78 8 8.5 D-Pro-Phe-Arg 4-nitroanilide Mus musculus