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Literature summary extracted from

  • Brennan, S.O.; Nakayama, K.
    Furin has the proalbumin substrate specificity and serpin inhibitory properties of an in situ hepatic convertase (1994), FEBS Lett., 338, 147-151.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.75 alpha1-antitrypsin not inhibited by normal antitrypsin M Mus musculus
3.4.21.75 antithrombin not Mus musculus
3.4.21.75 antithrombin/heparin not: antithrombin alone Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.75 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.75 Protein precursor + H2O rapid cleavage of the-Arg-Arg-Asp-site, no significant cleavage of natural unprocessed variants with cleavage site sequences of-Arg-Arg-Val-, His-Arg-Asp- or Cys-Arg-Asp Mus musculus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.75 5.5 6 proalbumin Mus musculus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.21.75 5
-
 30°C, 2 h, 50 mM MES buffer, 10% loss of activity Mus musculus
3.4.21.75 7
-
 30°C, 2 h, 50 mM MES buffer, about 90% loss of activity Mus musculus