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Literature summary extracted from

  • Lijnen, H.R.; De Cock, F.; Collen, D.
    Characterization of the binding of urokinase-type plasminogen activator (u-PA) to plasminogen, to plasminogen-activator inhibitor-1 and to the u-PA receptor (1994), Eur. J. Biochem., 224, 567-574.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.73
-
Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 plasminogen activator inhibitor 1 binding of single-chain uPA moiety to the inhibitor occurs with lower affinity compared to binding of the two-chain uPA moiety Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
recombinant 54000 MW scuPA, plasmin-resistant rscuPA with Lys158 mutagenized to Glu and a 32000 MW form of rscuPA consisting of Leu144-Leu411 are obtained by expression of cDNA in Chinese hamster ovary cells
-
3.4.21.73 Mammalia
-
recombinant 54000 MW scuPA, plasmin-resistant rscuPA with Lys158 mutagenized to Glu and a 32000 MW form of rscuPA consisting of Leu144-Leu411 are obtained by expression of cDNA in Chinese hamster ovary cells
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 additional information binding of single-chain uPA moiety to its substrate plasminogen occurs with lower affinity compared to binding of the two-chain uPA moiety Homo sapiens ?
-
?
3.4.21.73 additional information the enzyme cleaves its cellular receptor between domains 1 and 2 Homo sapiens ?
-
?
3.4.21.73 plasminogen + H2O
-
Homo sapiens plasmin + ?
-
?