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Literature summary extracted from

  • Plaut, A.G.
    The IgA1 proteases of pathogenic bacteria (1983), Annu. Rev. Microbiol., 37, 603-622.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.72 Haemophilus influenzae gene Haemophilus influenzae
3.4.21.72 Haemophilus influenzae gene Neisseria gonorrhoeae
3.4.21.72 Neisseria gonorrhoeae gene in Escherichia coli Haemophilus influenzae
3.4.21.72 Neisseria gonorrhoeae gene in Escherichia coli Neisseria gonorrhoeae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.72 IgA secreted colostral IgA Neisseria gonorrhoeae
3.4.21.72 IgA secreted colostral IgA Neisseria meningitidis
3.4.21.72 IgA secreted colostral IgA Streptococcus sanguinis
3.4.21.72 Normal human serum
-
 Neisseria gonorrhoeae
3.4.21.72 Normal human serum
-
 Neisseria meningitidis
3.4.24.13 EDTA
-
 Neisseria gonorrhoeae
3.4.24.13 EDTA
-
 Streptococcus pneumoniae
3.4.24.13 EDTA
-
 Streptococcus sanguinis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.72 extracellular
-
 Haemophilus influenzae
-
-
3.4.21.72 extracellular
-
 Neisseria gonorrhoeae
-
-
3.4.21.72 extracellular
-
 Neisseria meningitidis
-
-
3.4.21.72 extracellular
-
 Streptococcus sanguinis
-
-
3.4.24.13 periplasmic space recombinant enzyme produced in Escherichia coli is localized in the periplasmic space, a sequence linked to the carboxyl terminus of the iga gene but not present in the original clone is shown to be necessary to achieve normal secretion Haemophilus influenzae 42597
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.13 137000
-
 x * 137000, SDS-PAGE Haemophilus influenzae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.72 immunoglobulin A + H2O Haemophilus influenzae IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces ?
-
 ?
3.4.21.72 immunoglobulin A + H2O Neisseria gonorrhoeae IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces ?
-
 ?
3.4.21.72 immunoglobulin A + H2O Neisseria meningitidis IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces ?
-
 ?
3.4.21.72 immunoglobulin A + H2O Streptococcus sanguinis IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.72 Haemophilus influenzae
-
-
-
3.4.21.72 Neisseria gonorrhoeae
-
-
-
3.4.21.72 Neisseria meningitidis
-
-
-
3.4.21.72 Streptococcus sanguinis
-
-
-
3.4.24.13 Haemophilus influenzae
-
-
-
3.4.24.13 Neisseria gonorrhoeae
-
-
-
3.4.24.13 Neisseria meningitidis
-
-
-
3.4.24.13 Prevotella melaninogenica
-
-
-
3.4.24.13 Streptococcus mitior
-
-
-
3.4.24.13 Streptococcus pneumoniae
-
-
-
3.4.24.13 Streptococcus sanguinis
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.72 culture medium
-
 Haemophilus influenzae
-
3.4.21.72 culture medium
-
 Neisseria gonorrhoeae
-
3.4.21.72 culture medium
-
 Neisseria meningitidis
-
3.4.21.72 culture medium
-
 Streptococcus sanguinis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.72 Immunoglobulin A + H2O all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant Neisseria meningitidis immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant Streptococcus sanguinis immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge Neisseria meningitidis immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge Streptococcus sanguinis immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O Haemophilus influenzae type 1 enzyme cleaves Pro231-Ser232, type 2 enzyme cleaves Pro235-Thr236, type 3 enzyme cleaves peptide bond 237-238 Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O peptide analogs of human IgA as protease substrates Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O peptide analogs of human IgA as protease substrates Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O peptide analogs of human IgA as protease substrates Neisseria meningitidis immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O peptide analogs of human IgA as protease substrates Streptococcus sanguinis immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O Neisseria gonorrhoeae cleaves peptide bond 235-236 Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 immunoglobulin A + H2O IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces Haemophilus influenzae ?
-
 ?
3.4.21.72 immunoglobulin A + H2O IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces Neisseria gonorrhoeae ?
-
 ?
3.4.21.72 immunoglobulin A + H2O IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces Neisseria meningitidis ?
-
 ?
3.4.21.72 immunoglobulin A + H2O IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces Streptococcus sanguinis ?
-
 ?
3.4.24.13 immunoglobulin A1 + H2O
-
 Prevotella melaninogenica oligopeptides derived from immunoglobulin A1
-
 ?
3.4.24.13 immunoglobulin A1 + H2O
-
 Streptococcus mitior oligopeptides derived from immunoglobulin A1
-
 ?
3.4.24.13 immunoglobulin A1 + H2O type 1 protease cleaves peptide bond Pro231-Ser232 Haemophilus influenzae oligopeptides derived from immunoglobulin A1
-
 ?
3.4.24.13 immunoglobulin A1 + H2O type 2 protease cleaves peptide bond 235-236 Haemophilus influenzae oligopeptides derived from immunoglobulin A1
-
 ?
3.4.24.13 immunoglobulin A1 + H2O type 2 protease cleaves peptide bond 235-236 Neisseria meningitidis oligopeptides derived from immunoglobulin A1
-
 ?
3.4.24.13 immunoglobulin A1 + H2O type 1 protease cleaves peptide bond 237-238 Neisseria meningitidis oligopeptides derived from immunoglobulin A1
-
 ?
3.4.24.13 immunoglobulin A1 + H2O type 3 protease cleaves peptide bond 237-238 Haemophilus influenzae oligopeptides derived from immunoglobulin A1
-
 ?
3.4.24.13 immunoglobulin A1 + H2O cleavage of peptide bond Pro235-Thr236 Neisseria gonorrhoeae oligopeptides derived from immunoglobulin A1
-
 ?
3.4.24.13 immunoglobulin A1 + H2O cleaves peptide bond Pro227-Thr228 Streptococcus pneumoniae oligopeptides derived from immunoglobulin A1
-
 ?
3.4.24.13 immunoglobulin A1 + H2O cleaves peptide bond Pro227-Thr228 Streptococcus sanguinis oligopeptides derived from immunoglobulin A1
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.13 ?
-
 Neisseria gonorrhoeae
3.4.24.13 ? x * 137000, SDS-PAGE Haemophilus influenzae