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Literature summary extracted from
- Substrate inhibition of fibrin-dependent plasminogen activation by tissue-type plasminogen activator (1993), J. Biol. Chem., 268, 12257-12259.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.68 | Fibrin | enhances activity | Homo sapiens |  |
| 3.4.21.68 | Fibrin | or fibrin derivatives | Homo sapiens | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.68 | plasminogen | substrate inhibition, at low concentrations of t-PA and D-dimer of fibrin containing the D-domain of fibrin in the presence of physiological concentrations of plasminogen | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.68 | Homo sapiens | - |
Boehringer Mannheim | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.68 | commercial preparation | from: Boehringer Mannheim | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.68 | plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
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