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Literature summary extracted from
- The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage (1988), Biochim. Biophys. Acta, 952, 245-254.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.68 | Fibrin | fibrin-binding induces an activated state of the intact one-chain form | Homo sapiens |  |
| 3.4.21.68 | Polymerized fibrin | enhances amidolytic activity of both one-chain tPA forms but not of two-chain tPA | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.68 | - |
Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.68 | Homo sapiens | - |
construction of a one-chain recombinant tissue-type plasminogen activator analogue in which Arg275 is changed to Gly by site-directed mutagenesis | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.68 | plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
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