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Literature summary extracted from

  • Gerard, R.D.; Meidell, R.S.
    Regulation of tissue plasminogen activator expression (1989), Annu. Rev. Physiol., 51, 245-262.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.68 Fibrin enhances activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.68
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.68 Human plasminogen activator inhibitors
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.68 0.00002
-
 Glu-plasminogen with fibrinogen activation Homo sapiens
3.4.21.68 0.00016
-
 Lys-plasminogen with fibrinogen activation Homo sapiens
3.4.21.68 0.019
-
 Lys-plasminogen without fibrin Homo sapiens
3.4.21.68 0.065
-
 Glu-plasminogen without fibrin Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.68 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.68 breast cancer cell line transformed, carcinoma Homo sapiens
-
3.4.21.68 endothelium of veins and arteries Homo sapiens
-
3.4.21.68 fibrosarcoma cell line transformed Homo sapiens
-
3.4.21.68 HeLa cell transformed cell line Homo sapiens
-
3.4.21.68 hepatoma cell line transformed Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.68 plasminogen + H2O Glu-plasminogen is the native form of human plasminogen Homo sapiens plasmin + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.68 More t-PA is secreted as a single chain precursor which is cleaved at Arg275-Ile276 to a disulfide-linked two-chain form Homo sapiens