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Literature summary extracted from

  • Fuller, R.S.; Brake, A.; Thorner, J.
    Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease (1989), Proc. Natl. Acad. Sci. USA, 86, 1434-1438.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.61
-
 Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.61 Ala-Lys-Arg chloromethyl ketone
-
 Saccharomyces cerevisiae
3.4.21.61 diisopropyl fluorophosphate
-
 Saccharomyces cerevisiae
3.4.21.61 EDTA
-
 Saccharomyces cerevisiae
3.4.21.61 EGTA
-
 Saccharomyces cerevisiae
3.4.21.61 additional information L-1-tosylamido-2-phenylethyl chloromethyl ketone; Nalpha-(p-tosyl)lysine chloromethyl ketone; not: 1,10-phenanthroline; trans-epoxysuccinate compounds Saccharomyces cerevisiae
3.4.21.61 phenylmethylsulfonyl fluoride not Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.61 membrane
-
 Saccharomyces cerevisiae 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.61 Ca2+ reactivates after EDTA or EGTA treatment Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.61 Precursor protein of the mating hormone alpha-factor of Saccharomyces cerevisiae + H2O Saccharomyces cerevisiae processing ?
-
 ?
3.4.21.61 Precursor protein of the mating hormone alpha-factor of Saccharomyces cerevisiae + H2O Saccharomyces cerevisiae overproducing processing ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.61 Saccharomyces cerevisiae
-
 overproducing strain
-
3.4.21.61 Saccharomyces cerevisiae overproducing
-
 overproducing strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.61 partial Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.61 additional information a variety of trypsin substrates containing only one basic amino acid Saccharomyces cerevisiae ?
-
 ?
3.4.21.61 additional information cleaves peptide substrates at both Lys-Arg and Arg-Arg sites, not: benzyloxycarbonyl-Lys-Arg 4-nitroanilide, benzyloxycarbonyl-Arg-Arg 4-nitroanilide Saccharomyces cerevisiae ?
-
 ?
3.4.21.61 additional information a variety of trypsin substrates containing only one basic amino acid Saccharomyces cerevisiae overproducing ?
-
 ?
3.4.21.61 additional information cleaves peptide substrates at both Lys-Arg and Arg-Arg sites, not: benzyloxycarbonyl-Lys-Arg 4-nitroanilide, benzyloxycarbonyl-Arg-Arg 4-nitroanilide Saccharomyces cerevisiae overproducing ?
-
 ?
3.4.21.61 Precursor protein of the mating hormone alpha-factor of Saccharomyces cerevisiae + H2O processing Saccharomyces cerevisiae ?
-
 ?
3.4.21.61 Precursor protein of the mating hormone alpha-factor of Saccharomyces cerevisiae + H2O processing Saccharomyces cerevisiae overproducing ?
-
 ?
3.4.21.61 Protein + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
3.4.21.61 Protein + H2O
-
 Saccharomyces cerevisiae overproducing ?
-
 ?