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Literature summary extracted from
- Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor (1995), J. Biol. Chem., 270, 14477-14484.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.17.20 | thrombin | - |
Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.17.20 | 2-Guanidinoethylmercaptosuccinic acid | i.e. GEMSA | Homo sapiens |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.17.20 | 12000 | - |
x * 25000 + x * 12000, derived by cleavage at Arg330, inactive form, SDS-PAGE | Homo sapiens |
| 3.4.17.20 | 25000 | - |
x * 25000 + x * 12000, derived by cleavage at Arg330, inactive form, SDS-PAGE | Homo sapiens |
| 3.4.17.20 | 35000 | - |
x * 35000, active enzyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.17.20 | Fibrin, partially degraded + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.17.20 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.17.20 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.17.20 | plasma | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.17.20 | additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.17.20 | Fibrin, partially degraded + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.17.20 | ? | x * 60000-62000, zymogen, SDS-PAGE | Homo sapiens |
| 3.4.17.20 | ? | x * 25000 + x * 12000, derived by cleavage at Arg330, inactive form, SDS-PAGE | Homo sapiens |
| 3.4.17.20 | ? | x * 35000, active enzyme | Homo sapiens |
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