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Literature summary extracted from

  • Broze, G.J.
    Thrombin-dependent inhibition of fibrinolysis (1996), Curr. Opin. Hematol., 3, 390-394.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.17.20 plasmin can activate purified enzyme, proteolytic cleavage at Arg92 produces active enzyme, cleavage at Arg330 yields inactive fragments Homo sapiens
3.4.17.20 thrombin activation Homo sapiens
3.4.17.20 Thrombomodulin proteolytic cleavage at Arg92 produces active enzyme, cleavage at Arg330 yields inactive fragments, activates 1000fold Homo sapiens
3.4.17.20 Trypsin can activate purified enzyme, proteolytic cleavage at Arg92 produces active enzyme, cleavage at Arg330 yields inactive fragments Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.20 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.20 plasma synthesized by the liver, released to the plasma, concentration in the latter: 2.5 microgram/ml Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.20 additional information removal of Lys or Arg from carboxy-terminus of peptides, specific for basic amino acids at carboxy-terminus Homo sapiens ?
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