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Literature summary extracted from

  • Jacoby, W.B.; Bonner, D.M.
    Kynureninase from Neurospora: Purification and properties (1953), J. Biol. Chem., 205, 699-707.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.7.1.3 3-hydroxy-DL-kynurenine
-
 Neurospora crassa
3.7.1.3 KCN 1 mM Neurospora crassa
3.7.1.3 kynurenine
-
 Neurospora crassa
3.7.1.3 N'-formyl-L-kynurenine
-
 Neurospora crassa
3.7.1.3 NaHSO3 1 mM Neurospora crassa
3.7.1.3 NH2OH 0.1 mM Neurospora crassa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.7.1.3 0.003
-
 3-hydroxy-L-kynurenine
-
 Neurospora crassa
3.7.1.3 0.006
-
 kynurenine
-
 Neurospora crassa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.7.1.3 Ca2+
-
 Neurospora crassa
3.7.1.3 Mg2+
-
 Neurospora crassa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.7.1.3 3-hydroxy-L-kynurenine + H2O Neurospora crassa
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 L-kynurenine + H2O Neurospora crassa
-
 anthranilate + L-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.7.1.3 Neurospora crassa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.7.1.3
-
 Neurospora crassa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Neurospora crassa 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Neurospora crassa 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 L-kynurenine + H2O
-
 Neurospora crassa anthranilate + L-alanine
-
 ?
3.7.1.3 N-formyl-L-kynurenine + H2O
-
 Neurospora crassa N-formylanthranilate + L-alanine
-
 ?

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.7.1.3 20 37
-
 Neurospora crassa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.7.1.3 8.1
-
-
 Neurospora crassa

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.7.1.3 5.2
-
-
 Neurospora crassa

Cofactor

EC Number Cofactor Comment Organism Structure
3.7.1.3 pyridoxal 5'-phosphate
-
 Neurospora crassa