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Literature summary extracted from
- A chaperonin from a thermophilic bacterium, Thermus thermophilus, that controls refoldings of several thermophilic enzymes (1991), J. Biol. Chem., 266, 22411-22418.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.1.7 | NaHCO3 | 200 mM, 2.15fold increase in activity | Thermus thermophilus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.1.7 | 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole | 0.1 mM, 31% inhibition | Thermus thermophilus | |
| 5.6.1.7 | Dicyclohexylcarbodiimide | 0.1 mM, 43% inhibition | Thermus thermophilus | |
| 5.6.1.7 | N-ethylmaleimide | 0.1 mM, 32% inhibition | Thermus thermophilus | |
| 5.6.1.7 | Na2SO3 | 200 mM, 86% inhibition | Thermus thermophilus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.6.1.7 | ATP + H2O + a folded polypeptide | Thermus thermophilus | - |
ADP + phosphate + an unfolded polypeptide | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.1.7 | Thermus thermophilus | - |
thermophilic bacterium | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.6.1.7 | gel filtration | Thermus thermophilus |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 5.6.1.7 | 0.1 | - |
at 80°C | Thermus thermophilus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.6.1.7 | ATP + H2O + a folded polypeptide | - |
Thermus thermophilus | ADP + phosphate + an unfolded polypeptide | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.6.1.7 | 80 | - |
- |
Thermus thermophilus |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 5.6.1.7 | 60 | 90 | no or very little activity below 40°C | Thermus thermophilus |
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