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Literature summary extracted from

  • Kubota, H.; Hynes, G.; Willison, K.
    the chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol (1995), Eur. J. Biochem., 230, 3-16.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.6.1.7 CoA
-
 Bos taurus
5.6.1.7 CoA
-
 Oryctolagus cuniculus
5.6.1.7 Cpn10
-
 Saccharomyces cerevisiae
5.6.1.7 denatured beta actin 4fold increase in ATPase activity at 30°C Oryctolagus cuniculus
5.6.1.7 denatured beta tubulin
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.6.1.7 0.115
-
 ATP
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.7 cytosol
-
 Mus musculus 5829
-
5.6.1.7 cytosol
-
 Homo sapiens 5829
-
5.6.1.7 cytosol
-
 Saccharomyces cerevisiae 5829
-
5.6.1.7 cytosol
-
 Bos taurus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.6.1.7 60000
-
 16 * 60000, 8 different subunit species, 16 subunits in a particle Homo sapiens
5.6.1.7 960000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.7 ATP + H2O + a folded polypeptide Mus musculus
-
 ADP + phosphate + an unfolded polypeptide
-
 ?
5.6.1.7 ATP + H2O + a folded polypeptide Homo sapiens
-
 ADP + phosphate + an unfolded polypeptide
-
 ?
5.6.1.7 ATP + H2O + a folded polypeptide Saccharomyces cerevisiae
-
 ADP + phosphate + an unfolded polypeptide
-
 ?
5.6.1.7 ATP + H2O + a folded polypeptide Bos taurus
-
 ADP + phosphate + an unfolded polypeptide
-
 ?
5.6.1.7 ATP + H2O + a folded polypeptide Oryctolagus cuniculus
-
 ADP + phosphate + an unfolded polypeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.7 Bos taurus
-
-
-
5.6.1.7 Homo sapiens
-
 human Hep-2 cells
-
5.6.1.7 Mus musculus
-
 mouse
-
5.6.1.7 Oryctolagus cuniculus
-
-
-
5.6.1.7 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.7 adrenal medulla
-
 Bos taurus
-
5.6.1.7 testis
-
 Mus musculus
-
5.6.1.7 testis
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.6.1.7 0.0193
-
 at 37°C Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.7 ATP + H2O + a folded polypeptide
-
 Mus musculus ADP + phosphate + an unfolded polypeptide
-
 ?
5.6.1.7 ATP + H2O + a folded polypeptide
-
 Homo sapiens ADP + phosphate + an unfolded polypeptide
-
 ?
5.6.1.7 ATP + H2O + a folded polypeptide
-
 Saccharomyces cerevisiae ADP + phosphate + an unfolded polypeptide
-
 ?
5.6.1.7 ATP + H2O + a folded polypeptide
-
 Bos taurus ADP + phosphate + an unfolded polypeptide
-
 ?
5.6.1.7 ATP + H2O + a folded polypeptide
-
 Oryctolagus cuniculus ADP + phosphate + an unfolded polypeptide
-
 ?

Subunits

EC Number Subunits Comment Organism
5.6.1.7 hexadecamer 16 * 60000, 8 different subunit species, 16 subunits in a particle Homo sapiens