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Literature summary extracted from

  • Barnes, L.D.; Garrison, P.N.; Siprashvili, Z.; Guranowski, A.; Robinson, A.K.; Ingram, S.W.; Croce, C.M.; Ohta, M.; Huebner, K.
    Fhit, a putative tumor supressor in humans, is a dinucleoside 5',5'''-P1,P3-triphosphate hydrolase (1996), Biochemistry, 35, 11529-11535.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.29 expression in COS1 cells Homo sapiens
3.6.1.29 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.29 Zn2+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.29 0.0013
-
 P1-P3-bis(5'-adenosyl) triphosphate
-
 Homo sapiens
3.6.1.29 0.0046
-
 Ap4A
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.29 Co2+
-
 Homo sapiens
3.6.1.29 Mg2+
-
 Homo sapiens
3.6.1.29 Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.29 P1-P3-bis(5'-adenosyl) triphosphate + H2O Homo sapiens
-
 ADP + AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.29 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.29 breast
-
 Homo sapiens
-
3.6.1.29 colon
-
 Homo sapiens
-
3.6.1.29 esophagus
-
 Homo sapiens
-
3.6.1.29 kidney
-
 Homo sapiens
-
3.6.1.29 lung
-
 Homo sapiens
-
3.6.1.29 stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.29 Ap4A + H2O
-
 Homo sapiens ?
-
 ?
3.6.1.29 Ap6A + H2O
-
 Homo sapiens ?
-
 ?
3.6.1.29 diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
 Homo sapiens AMP + ATP
-
 ?
3.6.1.29 diadenosine 5',5''-P1,P5-pentaphosphate + H2O
-
 Homo sapiens AMP + adenosine 5'-tetraphosphate
-
 ?
3.6.1.29 P1-P3-bis(5'-adenosyl) triphosphate + H2O
-
 Homo sapiens ADP + AMP
-
 ?