BRENDA - Enzyme Database

Fhit, a putative tumor supressor in humans, is a dinucleoside 5',5'''-P1,P3-triphosphate hydrolase

Barnes, L.D.; Garrison, P.N.; Siprashvili, Z.; Guranowski, A.; Robinson, A.K.; Ingram, S.W.; Croce, C.M.; Ohta, M.; Huebner, K.; Biochemistry 35, 11529-11535 (1996)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.6.1.29
expression in COS1 cells; expression in Escherichia coli
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.29
Zn2+
-
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.6.1.29
0.0013
-
P1-P3-bis(5'-adenosyl) triphosphate
-
Homo sapiens
3.6.1.29
0.0046
-
Ap4A
-
Homo sapiens
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.6.1.29
Co2+
-
Homo sapiens
3.6.1.29
Mg2+
-
Homo sapiens
3.6.1.29
Mn2+
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.6.1.29
P1-P3-bis(5'-adenosyl) triphosphate + H2O
Homo sapiens
-
ADP + AMP
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.6.1.29
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.29
breast
-
Homo sapiens
-
3.6.1.29
colon
-
Homo sapiens
-
3.6.1.29
esophagus
-
Homo sapiens
-
3.6.1.29
kidney
-
Homo sapiens
-
3.6.1.29
lung
-
Homo sapiens
-
3.6.1.29
stomach
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.29
Ap6A + H2O
-
289061
Homo sapiens
?
-
-
-
?
3.6.1.29
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
289061
Homo sapiens
AMP + ATP
-
-
-
-
3.6.1.29
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
-
289061
Homo sapiens
AMP + adenosine 5'-tetraphosphate
-
-
-
?
3.6.1.29
P1-P3-bis(5'-adenosyl) triphosphate + H2O
-
289061
Homo sapiens
ADP + AMP
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.6.1.29
expression in COS1 cells; expression in Escherichia coli
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.6.1.29
Zn2+
-
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.6.1.29
0.0013
-
P1-P3-bis(5'-adenosyl) triphosphate
-
Homo sapiens
3.6.1.29
0.0046
-
Ap4A
-
Homo sapiens
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.6.1.29
Co2+
-
Homo sapiens
3.6.1.29
Mg2+
-
Homo sapiens
3.6.1.29
Mn2+
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.6.1.29
P1-P3-bis(5'-adenosyl) triphosphate + H2O
Homo sapiens
-
ADP + AMP
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.6.1.29
breast
-
Homo sapiens
-
3.6.1.29
colon
-
Homo sapiens
-
3.6.1.29
esophagus
-
Homo sapiens
-
3.6.1.29
kidney
-
Homo sapiens
-
3.6.1.29
lung
-
Homo sapiens
-
3.6.1.29
stomach
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.6.1.29
Ap6A + H2O
-
289061
Homo sapiens
?
-
-
-
?
3.6.1.29
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
289061
Homo sapiens
AMP + ATP
-
-
-
-
3.6.1.29
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
-
289061
Homo sapiens
AMP + adenosine 5'-tetraphosphate
-
-
-
?
3.6.1.29
P1-P3-bis(5'-adenosyl) triphosphate + H2O
-
289061
Homo sapiens
ADP + AMP
-
-
-
?