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Literature summary extracted from

  • Mastrantonio, S.; Nucci, R.; Vaccaro, C.; Rossi, M.; Whitehead, E.P.
    Analysis of competition for substrate sites in an allosteric enzyme with co-operative kinetics. Effects of dAMP and dUMP on donkey spleen deoxycytidylate aminohydrolase (1983), Eur. J. Biochem., 137, 421-427.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.4.12 dAMP at low substrate, dCMP, concentration: activation at higher concentration of either: inhibition Equus asinus
3.5.4.12 dCTP allosteric activator Equus asinus
3.5.4.12 dCTP allosteric activator, increases substrate affinity Equus asinus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.12 dAMP at low substrate, dCMP, concentration: activation at higher concentration of either: competitive inhibition; competitive inhibitor, activates enzyme at low substrate concentration mimicing the cooperative effect of the substrate Equus asinus
3.5.4.12 dTTP allosteric inhibitor Equus asinus
3.5.4.12 dUMP competitive inhibition, kinetics and mechanism of inhibition Equus asinus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.12 additional information
-
additional information kinetic studies, steady-state kinetics, allosteric kinetics Equus asinus
3.5.4.12 0.024
-
dCMP in the presence of dCTP Equus asinus
3.5.4.12 0.037
-
dCMP in the presence of dCTP Equus asinus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.12 120000
-
-
Equus asinus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.12 dCMP + H2O Equus asinus
-
dUMP + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.12 Equus asinus
-
donkey
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.5.4.12 dCMP + H2O = dUMP + NH3 mechanism Equus asinus
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Equus asinus
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Equus asinus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.12 spleen
-
Equus asinus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.12 dCMP + H2O
-
Equus asinus dUMP + NH3
-
?

Subunits

EC Number Subunits Comment Organism
3.5.4.12 hexamer 6 identical subunits Equus asinus