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Literature summary extracted from

  • Arminjon, F.; Guinand, M.; Vacheron, M.J.; Michel, G.
    Specificity profiles of the membrane-bound gamma-D-glutamyl-(L)meso-diaminopimelateendopeptidase and LD-carboxypeptidase from Bacillus sphaericus 9602 (1977), Eur. J. Biochem., 73, 557-565.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.11 DD-Diaminopimelic acid isomers
-
 Lysinibacillus sphaericus
3.4.19.11 Dicarboxylic D-amino acids inhibition is a function of length, maximum at n=4 Lysinibacillus sphaericus
3.4.19.11 meso-diaminopimelic acid isomers
-
 Lysinibacillus sphaericus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.17.13 0.8
-
 N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala
-
 Lysinibacillus sphaericus
3.4.17.13 1.25
-
 L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2) (L)-D-Ala Lysinibacillus sphaericus
3.4.19.11 0.33
-
 N-acetylmuramoyl-L-Ala-D-Glu-(L)-meso-diaminopimelic acid-(L)-D-Ala
-
 Lysinibacillus sphaericus
3.4.19.11 1.99
-
 N-acetylglucosamine-N-acetylmuramoyl-L-Ala-D-Glu-[-(L)-meso-diaminopimelic acid-D-Ala]NH2 immobilized enzyme Lysinibacillus sphaericus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.13 membrane
-
 Lysinibacillus sphaericus 16020
-
3.4.19.11 membrane bound Lysinibacillus sphaericus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.13 Lysinibacillus sphaericus
-
 9602
-
3.4.17.13 Lysinibacillus sphaericus 9602
-
 9602
-
3.4.19.11 Lysinibacillus sphaericus
-
 NCTC 9602
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.13 L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2)-(L)-D-Ala + H2O
-
 Lysinibacillus sphaericus L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2) + (L)-D-Ala
-
 ?
3.4.17.13 L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2)-(L)-D-Ala + H2O
-
 Lysinibacillus sphaericus 9602 L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2) + (L)-D-Ala
-
 ?
3.4.17.13 N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala + H2O
-
 Lysinibacillus sphaericus N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala
-
 ?
3.4.17.13 N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala + H2O
-
 Lysinibacillus sphaericus 9602 N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala
-
 ?
3.4.19.11 additional information hydrolysis of substrates containing D-Glu-meso-diaminopimelic-acid with free omega-NH2 and omega-COOH groups, the presence or absence of an alpha-amide group on glutamic acid, the second residue of peptides, has no influence on the specificity. N-Substitution of N-terminal L-Ala does not modify the enzymic specificity. An amide group on glutamic acid gives an decrease of 80% of activity Lysinibacillus sphaericus ?
-
 ?
3.4.19.11 additional information hydrolysis of substrates containing D-Glu-meso-diaminopimelic-acid with free omega-NH2 and omega-COOH groups, the presence or absence of an alpha-amide group on glutamic acid, the second residue of peptides, has no influence on the specificity. N-Substitution of N-terminal L-Ala does not modify the enzymic specificity. An amide group on glutamic acid gives an decrease of 80% of activity Lysinibacillus sphaericus 9602 ?
-
 ?
3.4.19.11 N-Acetylmuramoyl-L-Ala-D-Glu-(L)-meso-diaminopimelic acid-(L)-D-Ala + H2O best substrate Lysinibacillus sphaericus N-Acetylmuramoyl-L-Ala-D-Glu + meso-diaminopimelic acid-(L)-D-Ala
-
 ?
3.4.19.11 N-Acetylmuramoyl-L-Ala-D-Glu-(L)-meso-diaminopimelic acid-(L)-D-Ala + H2O best substrate Lysinibacillus sphaericus 9602 N-Acetylmuramoyl-L-Ala-D-Glu + meso-diaminopimelic acid-(L)-D-Ala
-
 ?