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Literature summary extracted from

  • Kim, J.; Linn, S.
    The mechanism of action of E. coli endonuclease III and T4 UV endonuclease (endonuclease V) at AP sites (1988), Nucleic Acids Res., 16, 1135-1141.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.21.7 double-stranded plasmid DNA + H2O Tequatrovirus T4 predominant release of a beta-elimination product rather than a hydrolytic product nicked circular DNA + linearized DNA
-
 ?
4.2.99.18 DNA Escherichia coli
-
 fragments of DNA
-
 ?
4.2.99.18 DNA Tequatrovirus T4
-
 fragments of DNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.7 Tequatrovirus T4
-
-
-
4.2.99.18 Escherichia coli
-
 endonuclease III
-
4.2.99.18 Tequatrovirus T4
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.99.18 the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate mechanism Escherichia coli
a
4.2.99.18 the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate mechanism Tequatrovirus T4
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.21.7 double-stranded plasmid DNA + H2O predominant release of a beta-elimination product rather than a hydrolytic product Tequatrovirus T4 nicked circular DNA + linearized DNA
-
 ?
4.2.99.18 DNA
-
 Escherichia coli fragments of DNA
-
 ?
4.2.99.18 DNA
-
 Tequatrovirus T4 fragments of DNA
-
 ?
4.2.99.18 DNA catalyzes phosphodiester bond cleavage via a lyase- rather than a hydrolase mechanism Escherichia coli fragments of DNA
-
 ?
4.2.99.18 DNA catalyzes phosphodiester bond cleavage via a lyase- rather than a hydrolase mechanism Tequatrovirus T4 fragments of DNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.21.7 T4 UV endonuclease
-
 Tequatrovirus T4