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Literature summary extracted from

  • Seedorf, U.; Brysch, P.; Engel, T.; Schrage, K.; Assmann, G.
    Sterol carrier protein x is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity (1994), J. Biol. Chem., 269, 21277-21283.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.16 expression in Escherichia coli Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.16 3-oxooctanoyl-CoA
-
 Rattus norvegicus
2.3.1.16 CoA
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.16 additional information
-
 additional information
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.16 peroxisome
-
 Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.16 CoA + 3-oxoacyl-CoA Rattus norvegicus enzyme plays important role in peroxisomal beta-oxidation, in addition the enzyme may facilitate the intraperoxysomal movement of sterols and certain other lipids acyl-CoA + acetyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.16 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.16 acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA ping-pong mechanism Rattus norvegicus
a
2.3.1.16 acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA sterol carrier protein X is a 3-oxoacyl CoA thiolase with intrinsic sterol carrier and lipid transfer activity Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.16 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.16 CoA + 3-oxoacyl-CoA
-
 Rattus norvegicus acyl-CoA + acetyl-CoA
-
 ?
2.3.1.16 CoA + 3-oxoacyl-CoA enzyme plays important role in peroxisomal beta-oxidation, in addition the enzyme may facilitate the intraperoxysomal movement of sterols and certain other lipids Rattus norvegicus acyl-CoA + acetyl-CoA
-
 ?
2.3.1.16 CoA + 3-oxooctanoyl-CoA
-
 Rattus norvegicus acetyl-CoA + hexanoyl-CoA
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.16 0.02
-
 CoA sterol carrier protein X-547 Rattus norvegicus
2.3.1.16 0.029
-
 3-oxooctanoyl-CoA sterol carrier protein X-547 Rattus norvegicus