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Literature summary extracted from

  • Allen, J.R.; Clark, D.D.; Krum, J.G.; Ensign, S.A.
    A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation (1999), Proc. Natl. Acad. Sci. USA, 96, 8432-8437.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.268 2-(R)-hydroxypropyl-CoM + NAD+ Xanthobacter sp.
-
2-oxopropyl-CoM + NADH
-
?
1.1.1.268 2-(R)-hydroxypropyl-CoM + NAD+ Xanthobacter sp. Py2
-
2-oxopropyl-CoM + NADH
-
?
1.8.1.5 2-mercaptoethanesulfonate + acetoacetate + NADP+ Xanthobacter sp. involved in epoxide carboxylation pathway in bacteria, reverse reaction more important 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
r
1.8.1.5 2-mercaptoethanesulfonate + acetoacetate + NADP+ Xanthobacter sp. Py2 involved in epoxide carboxylation pathway in bacteria, reverse reaction more important 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
r
4.4.1.23 epoxypropane + HS-CoM Xanthobacter autotrophicus this enzyme forms component I of a four-component enzyme system, comprising EC 4.2.99.19 2-hydroxypropyl-CoM lyase, component I, EC 1.8.1.5 2-oxopropyl-CoM reductase (carboxylating), component II, EC 1.1.1.268 2-(R)-hydroxypropyl-CoM dehydrogenase, component II and EC 1.1.1.269 2-(S)-hydroxypropyl-CoM dehydrogenase, component IV that is involved in epoxyalkane carboxylation 2-hydroxypropyl-CoM
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.268 Xanthobacter sp.
-
-
-
1.1.1.268 Xanthobacter sp. Py2
-
-
-
1.8.1.5 Xanthobacter sp.
-
Py2
-
1.8.1.5 Xanthobacter sp. Py2
-
Py2
-
4.4.1.23 Xanthobacter autotrophicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.268 cell culture
-
Xanthobacter sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.268 2-(R)-hydroxypropyl-CoM + NAD+
-
Xanthobacter sp. 2-oxopropyl-CoM + NADH
-
?
1.1.1.268 2-(R)-hydroxypropyl-CoM + NAD+
-
Xanthobacter sp. Py2 2-oxopropyl-CoM + NADH
-
?
1.8.1.5 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
Xanthobacter sp. 2-mercaptoethanesulfonate + acetoacetate + NADP+
-
r
1.8.1.5 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
Xanthobacter sp. Py2 2-mercaptoethanesulfonate + acetoacetate + NADP+
-
r
1.8.1.5 2-mercaptoethanesulfonate + acetoacetate + NADP+ dual function enzyme, reverse reaction of component II of carboxylation pathway Xanthobacter sp. 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
r
1.8.1.5 2-mercaptoethanesulfonate + acetoacetate + NADP+ involved in epoxide carboxylation pathway in bacteria, reverse reaction more important Xanthobacter sp. 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
r
1.8.1.5 2-mercaptoethanesulfonate + acetoacetate + NADP+ dual function enzyme, reverse reaction of component II of carboxylation pathway Xanthobacter sp. Py2 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
r
1.8.1.5 2-mercaptoethanesulfonate + acetoacetate + NADP+ involved in epoxide carboxylation pathway in bacteria, reverse reaction more important Xanthobacter sp. Py2 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+
-
r
4.4.1.23 epoxypropane + HS-CoM catalyzes the reaction of CoM with R-epoxypropane at a rate approximately twice of that with S-epoxypropane Xanthobacter autotrophicus 2-hydroxypropyl-CoM
-
?
4.4.1.23 epoxypropane + HS-CoM this enzyme forms component I of a four-component enzyme system, comprising EC 4.2.99.19 2-hydroxypropyl-CoM lyase, component I, EC 1.8.1.5 2-oxopropyl-CoM reductase (carboxylating), component II, EC 1.1.1.268 2-(R)-hydroxypropyl-CoM dehydrogenase, component II and EC 1.1.1.269 2-(S)-hydroxypropyl-CoM dehydrogenase, component IV that is involved in epoxyalkane carboxylation Xanthobacter autotrophicus 2-hydroxypropyl-CoM
-
?

Subunits

EC Number Subunits Comment Organism
4.4.1.23 More this enzyme forms component I of a four-component enzyme system, comprising EC 4.2.99.19 2-hydroxypropyl-CoM lyase, component I, EC 1.8.1.5 2-oxopropyl-CoM reductase (carboxylating), component II, EC 1.1.1.268 2-(R)-hydroxypropyl-CoM dehydrogenase, component II and EC 1.1.1.269 2-(S)-hydroxypropyl-CoM dehydrogenase, component IV that is involved in epoxyalkane carboxylation Xanthobacter autotrophicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.268 2-mercaptoethanesulfonate i.e. coenzyme M: function in catabolic pathway of hydrocarbon oxidation Xanthobacter sp.
1.1.1.268 NAD+
-
Xanthobacter sp.
1.8.1.5 2-mercaptoethanesulfonic acid coenzyme M Xanthobacter sp.
1.8.1.5 FAD enzyme bound Xanthobacter sp.