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Literature summary extracted from

  • Cuskey, S.M.; Peccoraro, V.; Olsen, R.H.
    Initial catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO: pathway description, mapping of mutations, and cloning of essential genes (1987), J. Bacteriol., 169, 2398-2404.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.87 additional information enzyme is only induced by growth with phenethanolamines Pseudomonas aeruginosa

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.9.2 cloning of portions of PAO 1 chromosome with genes coding for enzymes of catabolic pathway of aromatic biogenic amines Pseudomonas aeruginosa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.9.2 membrane
-
 Pseudomonas aeruginosa 16020
-
4.2.1.87 soluble
-
 Pseudomonas aeruginosa
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.53 4-hydroxyphenylacetaldehyde + NAD+ Pseudomonas aeruginosa
-
 4-hydroxyphenylacetate + NADH + H+
-
 ?
1.4.9.2 aromatic amines + acceptor + H2O Pseudomonas aeruginosa catabolism ? + reduced acceptor + NH3
-
 ?
4.2.1.87 octopamine Pseudomonas aeruginosa initial catabolism of octopamine (4-hydroxyphenyl)acetaldehyde + NH3 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.53 Pseudomonas aeruginosa
-
-
-
1.4.9.2 Pseudomonas aeruginosa
-
 PAO 1, inducible enzyme
-
4.2.1.87 Pseudomonas aeruginosa
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.2.1.87 additional information
-
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.53 4-hydroxyphenylacetaldehyde + NAD+
-
 Pseudomonas aeruginosa 4-hydroxyphenylacetate + NADH + H+
-
 ?
1.4.9.2 aromatic amines + acceptor + H2O catabolism Pseudomonas aeruginosa ? + reduced acceptor + NH3
-
 ?
1.4.9.2 additional information slow reaction with aromatic amines Pseudomonas aeruginosa ?
-
 ?
1.4.9.2 tyramine + acceptor + H2O
-
 Pseudomonas aeruginosa 4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
 ?
4.2.1.87 additional information not: phenethylamines, e.g. tyramine and dopamine Pseudomonas aeruginosa ?
-
 ?
4.2.1.87 norepinephrine
-
 Pseudomonas aeruginosa ?
-
 ?
4.2.1.87 octopamine i.e. 1-(4-hydroxyphenyl)-2-aminoethanol, oxygen-independent reaction, proposed mechanism: dehydration to an enamine and hydrolysis to an aldehyde and NH3 Pseudomonas aeruginosa (4-hydroxyphenyl)acetaldehyde + NH3 + H2O
-
 ?
4.2.1.87 octopamine initial catabolism of octopamine Pseudomonas aeruginosa (4-hydroxyphenyl)acetaldehyde + NH3 + H2O
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.87 7.5
-
 assay at Pseudomonas aeruginosa

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.53 NAD+
-
 Pseudomonas aeruginosa