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Literature summary extracted from

  • Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S.
    Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis (1984), J. Biochem., 96, 931-934.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.51 mitochondrion
-
 Euglena gracilis 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.51 pyruvate + CoA + NADP+ Euglena gracilis
-
 acetyl-CoA + CO2 + NADPH
-
 r
1.2.1.52 2-oxoglutarate + CoA + NADP+ Euglena gracilis NAD+ has 20% activity of NADP+ succinyl-CoA + CO2 + NADPH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.51 Euglena gracilis
-
-
-
1.2.1.52 Euglena gracilis
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
1.2.1.51 O2 leads to rapid inactivation Euglena gracilis

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.51
-
 Euglena gracilis

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.51 pyruvate + CoA + NADP+
-
 Euglena gracilis acetyl-CoA + CO2 + NADPH
-
 r
1.2.1.52 2-oxoglutarate + CoA + NADP+ NAD+ has 20% activity of NADP+ Euglena gracilis succinyl-CoA + CO2 + NADPH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.51 FAD
-
 Euglena gracilis
1.2.1.51 NADP+ not NAD+ Euglena gracilis
1.2.1.51 thiamine diphosphate
-
 Euglena gracilis
1.2.1.52 CoA
-
 Euglena gracilis
1.2.1.52 NAD+ 20% activity of NADP+ Euglena gracilis
1.2.1.52 NADP+
-
 Euglena gracilis