Literature summary extracted from

Ogushi, S.; Ando, M.; Tsuru, D.
Formaldehyde dehydrogenase from Pseudomonas putida: a zinc metalloenzyme (1984), J. Biochem., 96, 1587-1591.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.2.1.46	2,2'-bipyridine	reversible inactivation, formation of an enzyme-Zn-bipyridine complex	Pseudomonas putida
1.2.1.46	8-hydroxyquinoline	-	Pseudomonas putida
1.2.1.46	EDTA	-	Pseudomonas putida
1.2.1.46	o-phenanthroline	-	Pseudomonas putida
1.2.1.46	p-chloromercuribenzoate	-	Pseudomonas putida

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
1.2.1.46	Zinc	zinc metalloenzyme, 2 zinc atoms per subunit, one participates in catalytic activity, the other is involved in maintaining the native conformation of the enzyme	Pseudomonas putida

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.2.1.46	Pseudomonas putida	-	C-83	-
1.2.1.46	Pseudomonas putida C-83	-	C-83	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.2.1.46	formaldehyde + NAD+ + H2O	-	Pseudomonas putida	formate + NADH	-	?
1.2.1.46	formaldehyde + NAD+ + H2O	-	Pseudomonas putida C-83	formate + NADH	-	?

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Release 2023.1 (January 2023)