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Literature summary extracted from

  • Hijarrubia, M.J.; Aparicio, J.F.; Casqueiro, J.; Martin, J.F.
    Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional.alpha-aminoadipate activating and reducing enzyme (2001), Mol. Gen. Genet., 264, 755-762.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.31 cloning of lys2, the cloned gene encodes a functional alpha-aminoadipate reductase as shown by complementation of a Penicillium chrysogenum lys2 mutant, the aminoacid sequence shows strong homology with the alpha-aminoadipate reductase encoded by lys2 genes of Candida albicans, Schizosaccharomyces pombe, Saccharomyces cerevisiae and Penicillium chrysogenum Acremonium chrysogenum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.31 L-alpha-aminoadipate + NAD(P)H Acremonium chrysogenum
-
 L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
 ?
1.2.1.31 additional information Acremonium chrysogenum the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.31 Acremonium chrysogenum
-
-
-
1.2.1.95 Acremonium chrysogenum Q9HDP9
-
-
1.2.1.95 Acremonium chrysogenum ATCC 48272 Q9HDP9
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.2.1.31 side-chain modification the lys5 gene product is functionally active and can recognize apo-Lys2, transferring a 4'-phosphopantetheinyl moiety to the conserved serine residue in the peptidyl carrier domain of the protein Acremonium chrysogenum

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.31 additional information
-
-
 Acremonium chrysogenum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.31 L-2-aminoadipate + NADPH
-
 Acremonium chrysogenum L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
 ?
1.2.1.31 L-alpha-aminoadipate + NAD(P)H
-
 Acremonium chrysogenum L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
 ?
1.2.1.31 additional information the enzyme catalyzes both the activation of alpha-aminoadipic acid and its reduction to semialdehyde Acremonium chrysogenum ?
-
 ?
1.2.1.95 L-2-aminoadipate + NADPH + H+ + ATP
-
 Acremonium chrysogenum (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
-
 ?
1.2.1.95 L-2-aminoadipate + NADPH + H+ + ATP
-
 Acremonium chrysogenum ATCC 48272 (S)-2-amino-6-oxohexanoate + NADP+ + AMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.95 LYS2
-
 Acremonium chrysogenum

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.31 NADH reaction not observed Acremonium chrysogenum
1.2.1.31 NADPH
-
 Acremonium chrysogenum
1.2.1.95 additional information no activity with NADH Acremonium chrysogenum
1.2.1.95 NADPH
-
 Acremonium chrysogenum