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Literature summary extracted from

  • Ye, Z.H.; Bhattacharjee, J.K.
    Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe (1988), J. Bacteriol., 170, 5968-5970.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.87 1-hydroxy-1,2,4-butanetricarboxylate + NAD+ Schizosaccharomyces pombe alpha-aminoadipate pathway for biosynthesis of lysine 2-oxoadipate + CO2 + NADH
-
 ?
1.2.1.31 L-alpha-aminoadipate + NAD(P)H Schizosaccharomyces pombe sixth step of lysine biosynthesis L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
 ?
1.2.1.31 L-alpha-aminoadipate + NAD(P)H Schizosaccharomyces pombe alpha-aminoadipate pathway for lysine biosynthesis L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
 ?
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Schizosaccharomyces pombe last step of alpha-aminoadipate pathway for lysine biosynthesis L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.10 2-aminoadipate 6-semialdehyde + L-glutamate + NADPH Schizosaccharomyces pombe lysine biosynthesis N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate Schizosaccharomyces pombe first enzyme of the lysine biosynthetic pathway 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
4.2.1.36 2-Hydroxy-3-carboxyadipate Schizosaccharomyces pombe enzyme of the lysine biosynthetic pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.87 Schizosaccharomyces pombe
-
-
-
1.2.1.31 Schizosaccharomyces pombe
-
-
-
1.5.1.7 Schizosaccharomyces pombe
-
 fission yeast
-
1.5.1.10 Schizosaccharomyces pombe
-
 fission yeast
-
2.3.3.14 Schizosaccharomyces pombe
-
-
-
4.2.1.36 Schizosaccharomyces pombe
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.31 additional information
-
-
 Schizosaccharomyces pombe

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.87 1-hydroxy-1,2,4-butanetricarboxylate + NAD+
-
 Schizosaccharomyces pombe 2-oxoadipate + CO2 + NADH
-
 ?
1.1.1.87 1-hydroxy-1,2,4-butanetricarboxylate + NAD+ alpha-aminoadipate pathway for biosynthesis of lysine Schizosaccharomyces pombe 2-oxoadipate + CO2 + NADH
-
 ?
1.2.1.31 L-alpha-aminoadipate + NAD(P)H sixth step of lysine biosynthesis Schizosaccharomyces pombe L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
 ?
1.2.1.31 L-alpha-aminoadipate + NAD(P)H alpha-aminoadipate pathway for lysine biosynthesis Schizosaccharomyces pombe L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O
-
 ?
1.5.1.7 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O last step of alpha-aminoadipate pathway for lysine biosynthesis Schizosaccharomyces pombe L-lysine + 2-oxoglutarate + NADH
-
 ?
1.5.1.10 2-aminoadipate 6-semialdehyde + L-glutamate + NADPH lysine biosynthesis Schizosaccharomyces pombe N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O
-
 ?
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate
-
 Schizosaccharomyces pombe 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate first enzyme of the lysine biosynthetic pathway Schizosaccharomyces pombe 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
4.2.1.36 2-Hydroxy-3-carboxyadipate enzyme of the lysine biosynthetic pathway Schizosaccharomyces pombe ?
-
 ?
4.2.1.36 2-hydroxybutane-1,2,4-tricarboxylate
-
 Schizosaccharomyces pombe but-1-ene-1,2,4-tricarboxylate + H2O
-
 ?