Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Chang, Y.F.; Ghosh, P.; Rao, V.V.
    L-pipecolic acid metabolism in human liver: L-alpha-aminoadipate delta-semialdehyde oxidoreductase (1990), Biochim. Biophys. Acta, 1038, 300-305.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.31 2-mercaptoethanol 10 mM, activates Homo sapiens
1.2.1.31 dithiothreitol 10 mM, activates Homo sapiens
1.2.1.31 L-cysteine 10 mM, activates Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.31 EDTA
-
 Homo sapiens
1.2.1.31 FeCl3
-
 Homo sapiens
1.2.1.31 KCN strongly inhibits, 75% inhibition Homo sapiens
1.2.1.31 Pb(NO3)2
-
 Homo sapiens
1.2.1.31 Sodium diphosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.31 0.181
-
 L-2-aminoadipate 6-semialdehyde
-
 Homo sapiens
1.2.1.31 0.454
-
 NAD+
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.31 cytoplasm
-
 Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.31 Cu2+ stimulates Homo sapiens
1.2.1.31 Mg2+ stimulates Homo sapiens
1.2.1.31 Mn2+ stimulates Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.31 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.31 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.31 0.00077
-
 cytosol fraction Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.2.1.31 -20°C, 0.02 mM potassium phosphate buffer, pH 7.0, 5 mM 2-mercaptoethanol, 3 months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.31 L-2-aminoadipate 6-semialdehyde + NAD+ + H2O
-
 Homo sapiens L-2-aminoadipate + NADH
-
 ir

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.31 8
-
 in 0.2 M Tris-glycine buffer containing 5 mM beta-mercaptoethanol, L-alpha-aminoadipate-semialdehyde reduction Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.31 NAD+
-
 Homo sapiens