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Literature summary extracted from

  • Cash, C.D.; Maitre, M.; Ossola, L.; Mandel, P.
    Purification and properties of two succinate semialdehyde dehydrogenases from human brain (1978), Biochim. Biophys. Acta, 524, 26-36.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.24 4-hydroxybenzaldehyde
-
 Homo sapiens
1.2.1.24 AMP
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.24 additional information
-
 additional information
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.24 69000
-
 2 * 69000, SDS-PAGE Homo sapiens
1.2.1.24 145000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.24 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.24 2 isoenzymes Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.24 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.24 succinate semialdehyde + NAD+ + H2O
-
 Homo sapiens succinate + NADH
-
 ?
1.2.1.24 succinate semialdehyde + NADP+ + H2O 20% of the activity with NAD+ Homo sapiens succinate + NADPH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.24 dimer 2 * 69000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.24 8.6
-
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.24 NAD+
-
 Homo sapiens
1.2.1.24 NADP+ cofactor Homo sapiens