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Literature summary extracted from

  • Ryzlak, M.T.; Pietruszko, R.
    Human brain high Km aldehyde dehydrogenase: purification, characterization, and identification as NAD+-dependent succinic semialdehyde dehydrogenase (1988), Arch. Biochem. Biophys., 266, 386-396.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.24 Disulfiram
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.24 0.0007 0.002 succinate semialdehyde
-
 Homo sapiens
1.2.1.24 0.04
-
 NAD+
-
 Homo sapiens
1.2.1.24 0.58
-
 propionaldehyde
-
 Homo sapiens
1.2.1.24 0.875
-
 acetaldehyde
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.24 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.24 61000
-
 x * 61000 + x * 63000, SDS-PAGE Homo sapiens
1.2.1.24 63000
-
 x * 61000 + x * 63000, SDS-PAGE Homo sapiens
1.2.1.24 200000
-
 gel filtration Homo sapiens
1.2.1.24 232000 245000 non-denaturing PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.24 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.24
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.24 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.24 acetaldehyde + NAD+ + H2O 2.3% of the activity with succinate semialdehyde Homo sapiens acetate + NADH + H+
-
 ?
1.2.1.24 glutaric semialdehyde + NAD+ + H2O 13% of the activity with succinate semialdehyde Homo sapiens glutarate + NADH
-
 ?
1.2.1.24 m-nitrobenzaldehyde + NAD+ + H2O 4.3% of the activity with succinate semialdehyde Homo sapiens m-nitrobenzoate + NADH
-
 ?
1.2.1.24 p-nitrobenzaldehyde + NAD+ + H2O 6.5% of the activity with succinate semialdehyde Homo sapiens p-nitrobenzoate + NADH
-
 ?
1.2.1.24 propionaldehyde + NAD+ + H2O 5% of the activity with succinate semialdehyde Homo sapiens propionate + NADH
-
 ?
1.2.1.24 succinate semialdehyde + NAD+ + H2O
-
 Homo sapiens succinate + NADH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.24 ? x * 61000 + x * 63000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.24 9.5
-
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.24 NAD+
-
 Homo sapiens