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Literature summary extracted from

  • Bender, K.; Seibert, R.T.; Wienker, T.F.; Kren, V.; Pravenec, M.; Bissbort, S.
    Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus) (1994), Biochem. Genet., 32, 147-154.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.23 detection of two Mgd loci, which show a restrictive tissue expression, Mgd1 and Mgd2 are preferentially expressed in liver and kidney Rattus norvegicus
1.2.1.49 detection of three Mgd loci, which show a restrictive tissue expression, Mgd1 and Mgd2 are preferentially expressed in liver and kidney, Mgd3 is expressed apparently exclusively in heart Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.23 methylglyoxal + NAD+ + H2O Rattus norvegicus
-
 pyruvate + NADH + H+
-
 ?
1.2.1.49 methylglyoxal + NADP+ + H2O Rattus norvegicus
-
 pyruvate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.23 Rattus norvegicus
-
 inbred strains, recombinant inbred strains
-
1.2.1.49 Rattus norvegicus
-
 inbred strains, recombinant inbred strains
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.23 kidney
-
 Rattus norvegicus
-
1.2.1.23 liver
-
 Rattus norvegicus
-
1.2.1.49 heart
-
 Rattus norvegicus
-
1.2.1.49 kidney
-
 Rattus norvegicus
-
1.2.1.49 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.23 2-oxoaldehydes + NAD+ + H2O
-
 Rattus norvegicus 2-oxo acids + NADH
-
 ?
1.2.1.23 methylglyoxal + NAD+ + H2O
-
 Rattus norvegicus pyruvate + NADH + H+
-
 ?
1.2.1.49 2-oxoaldehydes + NADP+ + H2O
-
 Rattus norvegicus 2-oxo acids + NADPH
-
 ?
1.2.1.49 methylglyoxal + NADP+ + H2O
-
 Rattus norvegicus pyruvate + NADPH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.23 tetramer 4 * ?, codominant expression is observed in heterozygotes providing evidence for this enzyme structure Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.23 NADP+ Mgd1 and Mgd2 enzymes use also NADP+ as cofactor, see also EC 1.2.1.49 Rattus norvegicus
1.2.1.49 NAD+ Mgd1 and Mgd2 enzymes use also NAD+ as cofactor, see also EC 1.2.1.23 Rattus norvegicus
1.2.1.49 NADP+ isoenzyme Mgd3 is exclusively NADP+-dependent Rattus norvegicus