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Literature summary extracted from

  • Ray, M.; Ray, S.
    On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase (1982), J. Biol. Chem., 257, 10571-10574.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.23 dihydroxyacetone phosphate stimulation Capra hircus
1.2.1.23 fructose 1,6-bisphosphate 100% stimulation, 0.03 mM, extent of stimulation is pH-dependent Capra hircus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.23 ADP strong inhibitor, 1 mM Capra hircus
1.2.1.23 ATP strong inhibitor, 0.6 mM Capra hircus
1.2.1.23 glyceraldehyde 3-phosphate strong inhibitor Capra hircus
1.2.1.23 GTP strong inhibitor, 1 mM Capra hircus
1.2.1.23 NADP+ strong competitive inhibitor, 0.001 mM Capra hircus
1.2.1.49 dihydroxyacetone
-
 Capra hircus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.49 0.04
-
 NADP+
-
 Capra hircus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.23 methylglyoxal + NAD+ + H2O Capra hircus i.e. pyruvaldehyde pyruvate + NADH + H+
-
 ?
1.2.1.49 methylglyoxal + NADP+ + H2O Capra hircus
-
 pyruvate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.23 Capra hircus
-
-
-
1.2.1.49 Capra hircus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.23 2-oxoaldehydes + NAD+ + H2O
-
 Capra hircus 2-oxo acids + NADH
-
 ?
1.2.1.23 methylglyoxal + NAD+ + H2O i.e. pyruvaldehyde Capra hircus pyruvate + NADH + H+
-
 ?
1.2.1.49 2-oxoaldehydes + NADP+ + H2O
-
 Capra hircus 2-oxo acids + NADPH
-
 ?
1.2.1.49 methylglyoxal + NADP+ + H2O
-
 Capra hircus pyruvate + NADPH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.23 NAD+
-
 Capra hircus
1.2.1.49 NADP+
-
 Capra hircus