Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Oimomi, M.; Hata, F.; Nakamichi, T.; Baba, S.; Kato, H.
    Purification of alpha-ketoaldehyde dehydrogenase from the human liver and its possible significance in the control of glycation (1989), Experientia, 45, 463-466.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.23 p-chloromercuribenzoate
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.23 0.24
-
methylglyoxal
-
Homo sapiens
1.2.1.23 0.47
-
3-deoxygluconosone
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.23 43000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.23 3-deoxygluconosone + NAD+ + H2O Homo sapiens
-
3-deoxygluconic acid + NADH + H+
-
?
1.2.1.23 methylglyoxal + NAD+ + H2O Homo sapiens
-
pyruvate + NADH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.23 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.23 using acetone powder preparation, ammonium sulfate, column chromatography on DEAE-cellulose, affinity column packed with TSK-Gel AF-Red Toyopearl 650 ML and fast protein liquid chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.23 liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.23 4.65
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.23 2-oxoaldehydes + NAD+ + H2O
-
Homo sapiens 2-oxo acids + NADH
-
?
1.2.1.23 3-deoxygluconosone + NAD+ + H2O
-
Homo sapiens 3-deoxygluconic acid + NADH + H+
-
?
1.2.1.23 aldehydes + NAD+ + H2O
-
Homo sapiens carboxylic acids + NADH
-
?
1.2.1.23 methylglyoxal + NAD+ + H2O
-
Homo sapiens pyruvate + NADH + H+
-
?

Subunits

EC Number Subunits Comment Organism
1.2.1.23 monomer 1 * 43000, SDS-PAGE Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.23 NAD+
-
Homo sapiens