Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wang, C.S.; Alaupovic, P.
    Glyceraldehyde-3-phosphate dehydrogenase from human erythrocyte membranes. Kinetic mechanism and competitive substrate inhibition by glyceraldehyde 3-phosphate (1980), Arch. Biochem. Biophys., 205, 136-145.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.12 2,3-diphosphoglycerate
-
 Homo sapiens
1.2.1.12 ATP noncompetitive inhibitor Homo sapiens
1.2.1.12 D-glyceraldehyde 3-phosphate substrate inhibition Homo sapiens
1.2.1.12 NADH
-
 Homo sapiens
1.2.1.12 NO3- uncompetitive inhibitor with NAD+, dead end inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.12 membrane isolated from human erytrocyt ghosts Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+ Homo sapiens glycolytic enzyme 3-phospho-D-glyceroyl phosphate + NADH
-
 ?
1.2.1.12 additional information Homo sapiens enzyme is regulated by ATP and by D-glyceraldehyde 3-phosphate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.12 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ ordered ter bi mechanism characterized by the sequential addition of NAD+, glyceraldehyde 3-phosphate and phosphate to the enzyme and the sequential release of 3-phospho-D-glyceroyl phosphate and NADH from the enzyme Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.12 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.12 98
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Homo sapiens 3-phospho-D-glyceroyl phosphate + NADH
-
 ?
1.2.1.12 D-glyceraldehyde 3-phosphate + phosphate + NAD+ glycolytic enzyme Homo sapiens 3-phospho-D-glyceroyl phosphate + NADH
-
 ?
1.2.1.12 additional information enzyme is regulated by ATP and by D-glyceraldehyde 3-phosphate Homo sapiens ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.12 NAD+
-
 Homo sapiens