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Literature summary extracted from

  • Koivusalo, M.; Uotila, L.
    Glutathione-dependent formaldehyde dehydrogenase/class III alcohol dehydrogenase: Further characterization of the rat liver enzyme (1993), Adv. Exp. Med. Biol., 328, 465-474.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.284 12-oxododecanoic acid linear competitive Rattus norvegicus
1.1.1.284 S-formylglutathione product inhibition with S-hydroxymethylglutathione Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.284 0.006
-
glutathione
-
Rattus norvegicus
1.1.1.284 0.125
-
glutathione monomethyl ester
-
Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.284 Rattus norvegicus
-
class II alcohol dehydrogenase
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.284 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.284 formaldehyde + 6-mercaptohexanoate + NAD+ 30% of the activity with glutathione Rattus norvegicus S-formyl-6-mercaptohexenoate + NADH
-
?
1.1.1.284 formaldehyde + 8-mercaptooctanoate + NAD+ 35% of the activity with glutathione Rattus norvegicus S-formyl-8-mercaptooctanoate + NADH
-
?
1.1.1.284 formaldehyde + captopril + NAD+ 8% of the activity with glutathione Rattus norvegicus S-formylcaptopril + NADH
-
?
1.1.1.284 formaldehyde + glutathione + NAD+ the true substrate is a hemimercaptal, S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione Rattus norvegicus S-formylglutathione + NADH + H+
-
r
1.1.1.284 formaldehyde + glutathione + NADP+
-
Rattus norvegicus S-formylglutathione + NADPH + H+
-
r
1.1.1.284 formaldehyde + glutathione monomethyl ester + NAD+ 70% of the activity with glutathione Rattus norvegicus S-formylglutathione monomethyl ester + NADH
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.284 NAD+
-
Rattus norvegicus