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Literature summary extracted from

  • Zakharyan, R.A.; Aposhian, H.V.
    Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase (1999), Chem. Res. Toxicol., 12, 1278-1283.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.20.4.2 dithiothreitol stimulates Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.20.4.2 2.1
-
 monomethylarsonate
-
 Oryctolagus cuniculus
1.20.4.2 20.9
-
 dimethylarsonate
-
 Oryctolagus cuniculus
1.20.4.2 109
-
 arsenate
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.20.4.2 methylarsonate + glutathione Oryctolagus cuniculus rate-limiting enzyme in biotransformation of inorganic arsenite in rabbit liver methylarsonite + oxidized glutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.20.4.2 Homo sapiens
-
-
-
1.20.4.2 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.20.4.2 partial Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.20.4.2 liver
-
 Homo sapiens
-
1.20.4.2 liver
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.20.4.2 additional information
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.20.4.2 arsenate + glutathione
-
 Oryctolagus cuniculus arsenite + reduced glutathione
-
 ?
1.20.4.2 dimethylarsonate + glutathione
-
 Oryctolagus cuniculus dimethylarsonous acid
-
 ?
1.20.4.2 methylarsonate + glutathione rate-limiting enzyme in biotransformation of inorganic arsenite in rabbit liver Oryctolagus cuniculus methylarsonite + oxidized glutathione
-
 ?
1.20.4.2 monomethylarsonate + glutathione
-
 Homo sapiens monomethylarsonous acid + oxidized glutathione
-
 ?
1.20.4.2 monomethylarsonate + glutathione
-
 Oryctolagus cuniculus monomethylarsonous acid + oxidized glutathione
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.20.4.2 8
-
-
 Oryctolagus cuniculus