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Literature summary extracted from

  • Whitlon, D.S.; Sadowski, J.A.; Suttie, J.W.
    Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition (1978), Biochemistry, 17, 1371-1377.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.4.4 dithiothreitol
-
 Rattus norvegicus
1.17.4.4 lipoic acid
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 coumarin anticoagulants
-
 Rattus norvegicus
1.17.4.4 Difenacoum
-
 Rattus norvegicus
1.17.4.4 warfarin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.4 microsome
-
 Rattus norvegicus
-
-
1.17.4.4 microsome integral membrane protein Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol Rattus norvegicus
-
 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
 ?
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol Rattus norvegicus Holtzman
-
 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Rattus norvegicus
-
 Holtzman strain
-
1.17.4.4 Rattus norvegicus
-
 warfarin-resistant rat
-
1.17.4.4 Rattus norvegicus Holtzman
-
 Holtzman strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
 Rattus norvegicus 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
 ?
1.17.4.4 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
 Rattus norvegicus Holtzman 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus Holtzman vitamin K + oxidized dithiothreitol
-
 ?